06-918 | Anti-Rsk2/MAPKAP Kinase 1b Antibody

06-918
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-918
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Rsk2/MAPKAP Kinase 1b Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationDetect Rsk2/MAPKAP Kinase 1b using this Anti-Rsk2/MAPKAP Kinase 1b Antibody validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide (C-NRNQSPVLEPVGRS) corresponding to amino acids 711-724 of mouse Rsk2
      HostRabbit
      SpecificityRsk2/MAPKAP K1β
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).
      Gene Symbol
      • RPS6KA3
      • CLS
      • RSK-2
      • RSK2
      • p90-RSK2
      • ISPK1
      • MRX19
      • HU-3
      • pp90RSK2
      • MAPKAPK1B
      • HU-2
      • RSK
      • S6K-alpha3
      • ISPK-1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51812 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
      COFACTOR: Magnesium (By similarity).
      SIZE: 740 amino acids; 83736 Da
      SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
      TISSUE SPECIFICITY: Expressed in many tissues, highest levels in skeletal muscle.
      PTM: Autophosphorylated on Ser-386, as part of the activation process (By similarity). & Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369 (By similarity).
      DISEASE: SwissProt: P51812 # Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
      SIMILARITY: SwissProt: P51812 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
      Molecular Weight90kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on mouse 3T3 cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Rsk2/MAPKAP Kinase 1b (rabbit polyclonal IgG) -2504290 2504290
      Anti-Rsk2/MAPKAP Kinase 1b - 18111 18111
      Anti-Rsk2/MAPKAP Kinase 1b - 21911 21911
      Anti-Rsk2/MAPKAP Kinase 1b - DAM151402 DAM151402
      Anti-Rsk2/MAPKAP Kinase 1b -2556295 2556295

      References

      Reference overviewApplicationPub Med ID
      Phosphorylation of histone H2B serine 32 is linked to cell transformation.
      Lau, AT; Lee, SY; Xu, YM; Zheng, D; Cho, YY; Zhu, F; Kim, HG; Li, SQ; Zhang, Z; Bode, AM; Dong, Z
      The Journal of biological chemistry  286  26628-37  2011

      Show Abstract
      21646345 21646345
      Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 Are Involved in the Phosphorylation of STAT3
      Zhang, Y., et al
      J Biol Chem, 278:12650-9 (2003)  2003

      Kinase Assay12562765 12562765
      RSK2 activity is regulated by its interaction with PEA-15.
      Vaidyanathan, Hema and Ramos, Joe W
      J. Biol. Chem., 278: 32367-72 (2003)  2003

      Show Abstract
      Immunofluorescence12796492 12796492
      Rapid immunoblot and kinase assay tests for a syndromal form of X linked mental retardation: Coffin-Lowry syndrome.
      Merienne, K, et al.
      J. Med. Genet., 35: 890-4 (1998)  1998

      Show Abstract
      9832033 9832033
      Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase.
      Xing, J, et al.
      Science, 273: 959-63 (1996)  1996

      Show Abstract
      8688081 8688081
      Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases
      Zhao, Y., et al
      J Biol Chem, 271:29773-9 (1996)  1996

      Kinase Assay8939914 8939914

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies