05-1115 | Anti-SG2NA Antibody

05-1115
100 µL  
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      Overview

      Replacement Information
      Replacement Information05-1115 is a recommended replacement for MAB5464

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MWB, ICC, IPMAscitesMonoclonal Antibody
      Description
      Catalogue Number05-1115
      ReplacesMAB5464
      DescriptionAnti-SG2NA Antibody
      Alternate Names
      • Cell-cycle autoantigen SG2NA
      • Striatin 3
      Background InformationSG2NA, also known as Striatin 3, was identified as a human cancer auto-antigen and has not been implicated in vesicular trafficking and signal tranduction. It is highly related to striatin and zinedin (striatin 4). It is a cytoplasmic scaffolding protein that binds to Calmodulin and PP2A A and C subunits as well as the human homolog of the yeast protein, Mob1, which appears to modulate PP2A activity.
      References
      Product Information
      FormatAscites
      Control
      • L6 cell lysate
      PresentationMouse monoclonal IgG1 ascites containing 40% glycerol and 0.02% sodium azide.
      Applications
      ApplicationAnti-SG2NA Antibody is an antibody against SG2NA for use in WB, IC & IP.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunoprecipitation
      Application NotesImmunocytochemistry: A previous lot of this antibody was used in immunocytochemistry at a 1:500 dilution.

      Immunoprecipitation: A previous lot of this antibody was used in IP; 3 μL is a recommended as starting point for immunoprecipitation.
      Optimal working dilutions must be determined by end user.

      Biological Information
      ImmunogenSynthetic peptide from SG2NA.
      HostMouse
      SpecificityReacts with SG2NA. No cross reactivity with striatin.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • STRN3
      • Striatin-3
      • GS2NA
      • SG2NA
      UniProt Number
      UniProt SummaryFUNCTION: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
      SUBUNIT: Interacts with protein phosphatase 2A (PP2A) (Potential).
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
      ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist. Name Beta
      Isoform ID Q13033-1
      This is the isoform sequence displayed in this entry.
      Name Alpha
      Isoform ID Q13033-2
      Features which should be applied to build the isoform sequence: VSP_006786.
      SIMILARITY: Belongs to the WD repeat striatin family.
      SIMILARITY: Contains 6 WD repeats.
      CAUTION: Was originally (PubMed:7864889) thought to be nuclear.
      Molecular WeightThe antibody recognizes the ~93 kDa SG2NA protein in Jurkat cell lysate. In some cell types a band of ~70 kDa is also recognized, which may be an alternatively spliced form of SG2NA or another unknown protein.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by Western Blot on L6 lysates.

      Western Blot Analysis: 1:500 dilution of this lot detected SG2NA on 10 μg of L6 lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable at -20°C in undiluted aliquots for up to 1 year from date of receipt. For long-term storage, may be stored at -80°C.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications