Key Spec Table
|Species Reactivity||Key Applications||Host||Format||Antibody Type|
|H, M, R||FC||M||FITC||Monoclonal Antibody|
|Presentation||Purified mouse monoclonal IgG2b conjugated to FITC in PBS with less than 0.09% sodium azide and 15 mg/mL BSA.|
|Immunogen||Recombinant GST Fusion protein.|
|Species Reactivity Note||Tested and passed on Human. based on 100% sequence homology. Human and Rat|
|Antibody Type||Monoclonal Antibody|
|Entrez Gene Number|
|Entrez Gene Summary||This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript
|Purification Method||Protein A Purfied|
|UniProt Summary||FUNCTION: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency By similarity.
SUBCELLULAR LOCATION: Nucleus.
PTM: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation By similarity.
INVOLVEMENT IN DISEASE: Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
SEQUENCE SIMILARITIES: Contains 1 HMG box DNA-binding domain.
|Molecular Weight||~34 kDa|
|Safety Information according to GHS|
|Product Usage Statements|
|Quality Assurance||Evaluated by flow cytometry on undifferentiated adult Rat hippocampal neural stem cells SCR022.
Optimal working dilutions must be determined by the end user.
|Storage and Shipping Information|
|Storage Conditions||Maintain refrigerated at 2-8oC protected from light in undiluted aliquots for up to 6 months from date of receipt.|
|Material Size||100 tests|
|Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1734258||NG1734258|
|Anti-SOX-2, clone 6G1.2 FITC conjugate - NRG1675587||NRG1675587|
|Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - 2154101||2154101|
|Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - 2049809||2049809|
|Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - 2216906||2216906|
|Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1820239||NG1820239|
|Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1881829||NG1881829|
|Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1904634||NG1904634|
|Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1951935||NG1951935|
|Milli-Mark Anti-SOX-2,clone 6G1.2 FITC conjugate - NG1865719||NG1865719|
|Innovative Solutions for Flow Cytometry Analysis|