FCMAB112F | Anti-SOX-2 Antibody, clone 6G1.2, FITC conjugate

FCMAB112F
100 tests  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB112F
      DescriptionAnti-SOX-2 Antibody, clone 6G1.2, FITC conjugate
      Alternate Names
      • SRY (sex determining region Y)-box 2
      • SRY-related HMG-box gene 2
      • sex-determining region Y-box 2
      • transcription factor SOX2
      Background InformationSox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain a pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
      References
      Product Information
      FormatFITC
      Control
      • Rat Neural Stem Cells.
      PresentationPurified mouse monoclonal IgG2b conjugated to FITC in PBS with less than 0.09% sodium azide and 15 mg/mL BSA.
      Flow Cytometry:
      Antibody dilution for cellular staining:
      • Prepare an antibody working solution by diluting 1:5 the primary antibody with PBS.
      • Dispense the volume per test of working of solution according to the number of cells indicated in the table below.
      • 5 µL for Guava Flow Cytometer
      • 10 µL for other Flow Cytometry instruments
      Applications
      ApplicationAnti-SOX-2 Antibody, clone 6G1.2, FITC conjugate is an antibody against SOX-2 for use in FC.
      Key Applications
      • Flow Cytometry
      Working Solution Cells / test Total Reaction Volume
      5 μl 5 x 105 Cells / 95 μl PBS 100 μl
      10 μl 1 x 106 Cells / 90 μl PBS 100 μl
      Biological Information
      ImmunogenRecombinant GST Fusion protein.
      Clone6G1.2
      HostMouse
      SpecificitySOX-2
      IsotypeIgG2b
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteTested and passed on Human. based on 100% sequence homology. Human and Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript
      (SOX2OT).
      Gene Symbol
      • ANOP3
      • MCOPS3
      • MGC2413
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency By similarity.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation By similarity.
      INVOLVEMENT IN DISEASE: Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.
      SEQUENCE SIMILARITIES: Contains 1 HMG box DNA-binding domain.
      Molecular Weight~34 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry on undifferentiated adult Rat hippocampal neural stem cells SCR022.
      Optimal working dilutions must be determined by the end user.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8oC protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1734258 NG1734258
      Anti-SOX-2, clone 6G1.2 FITC conjugate - NRG1675587 NRG1675587
      Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - 2154101 2154101
      Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - 2049809 2049809
      Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - 2216906 2216906
      Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1820239 NG1820239
      Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1881829 NG1881829
      Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1904634 NG1904634
      Milli-Mark Anti-SOX-2, clone 6G1.2 FITC conjugate - NG1951935 NG1951935
      Milli-Mark Anti-SOX-2,clone 6G1.2 FITC conjugate - NG1865719 NG1865719

      Brochure

      Title
      Benchtop Flow Cytometry Solutions Kits and Reagents
      Innovative Solutions for Flow Cytometry Analysis

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      Categories

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