07-1673 | Anti-SOX1 Antibody

07-1673
100 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HIH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1673
      DescriptionAnti-SOX1 Antibody
      Alternate Names
      • SRY (sex determining region Y)-box 1
      • SRY-related HMG-box gene 1
      Background InformationSox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody precipitated in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
      Applications
      ApplicationUse Anti-SOX1 Antibody (Rabbit Polyclonal Antibody) validated in IHC(P) to detect SOX1 also known as SRY (sex determining region Y)-box 1, SRY-related HMG-box gene 1.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenSynthetic peptide corresponding to SOX1.
      HostRabbit
      SpecificityThis antibody recognizes SOX1.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman. Predicted to react with mouse based on sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SOX1
      • SRY
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Transcriptional activator By similarity.

      SUBCELLULAR LOCATION: NucleusProbable.

      TISSUE SPECIFICITY: Mainly in the developing central nervous system.

      SIMILARITY: Contains 1 HMG box DNA-binding domain.

      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by immunohistochemistry on human epidermis.

      Immunohistochemistry(paraffin):
      A 1:300 dilution of this antibody was used to detect SOX1 in human epidermis.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10 μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SOX1 - 2429684 2429684
      Anti-SOX1 - 2459503 2459503
      Anti-SOX1 - 2281688 2281688
      Anti-SOX1 - 2316819 2316819
      Anti-SOX1 - NG1586852 NG1586852
      Anti-SOX1 - NG1822436 NG1822436
      Anti-SOX1 - NG1946577 NG1946577
      Anti-SOX1 -2860223 2860223
      Anti-SOX1 Polyclonal Antibody 3117356
      Anti-SOX1 Polyclonal Antibody 2911541

      References

      Reference overviewPub Med ID
      Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells.
      Neri, F; Zippo, A; Krepelova, A; Cherubini, A; Rocchigiani, M; Oliviero, S
      Molecular and cellular biology  32  840-51  2012

      Show Abstract
      22184065 22184065

      Related Products & Applications

      Related Products

      Catalogue Number Description  
      AB15766 Anti-Sox1 Antibody Show Pricing & Availability
      AB5934 Anti-Sox1 Antibody Show Pricing & Availability
      MABN155 Anti-Sox1 Antibody, clone 2B3.3 Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies