06-1366 | Anti-SRp55 Antibody

06-1366
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IPRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1366
      DescriptionAnti-SRp55 Antibody
      Alternate Names
      • serine/arginine-rich splicing factor 6
      • splicing factor, arginine/serine-rich 6
      • arginine/serine-rich splicing factor 6
      • splicing factor, arginine/serine-rich, 55 kDa
      • Pre-mRNA-splicing factor SRP55
      • pre-mRNA splicing factor SRP55
      • SR splicing factor 6
      Background InformationPre-mRNA-splicing factor SRp55, also known as Serine/arginine-rich splicing factor 6, is a member of the serine/arginine-rich (SR) protein family. This group of proteins is found mainly in the nucleus where they play a critical role in regulated and constitutive splicing of precursor mRNAs. SRp55 is involved in the constitutive process for mRNA splicing, and is able to mediate alternative splice site selection. Considered one of the more ubiquitous of the splice factors, SRp55 is upregulated in response to DNA damage when p53 is lacking. SRp55 is significantly phosphorylated on RS domain serine residues.
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-SRp55 Antibody is a Rabbit Polyclonal Antibody for detection of SRp55 also known as serine/arginine-rich splicing factor 6, Pre-mRNA-splicing factor SRP55 & has been validated in WB & IP.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis:
      A representative lot was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human SRp55.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.
      Gene Symbol
      • SRP55
      • SFRS6
      • SRSF6
      • B52
      Purification MethodProtein A
      UniProt Number
      UniProt SummaryFUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

      SUBUNIT STRUCTURE: Binds SFRS12.

      SUBCELLULAR LOCATION: Nucleus.

      PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity).

      SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.

      Contains 2 RRM (RNA recognition motif) domains.
      Molecular Weight ~50 kDa observed. Mulitple uncharacterized bands have been observed in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 1:500 dilution of this antibody detected SRp55 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies