06-1367 | Anti-SRp75 Antibody

06-1367
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1367
      DescriptionAnti-SRp75 Antibody
      Alternate Names
      • serine/arginine-rich splicing factor 4
      • splicing factor, arginine/serine-rich 4
      • SR splicing factor 4
      • Pre-mRNA-splicing factor SRP75
      Background InformationSRp75, also known as Serine/arginine-rich splicing factor 4, is an essential splicing factor that is a member of the SR family of proteins. This protein is a component of the pre-mRNA splicing complex and is believed to play a role in alternative splice site selection. Consistent with this excess levels of SRp75 have been shown to play a role in alternative splicing of CD45. SRp75 is normally found in the nucleus and is known to be hyperphosphorylated at serine residues in its RS domain.
      References
      Product Information
      FormatPurified
      Control
      • L6 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-SRp75 Antibody is a rabbit polyclonal antibody for detection of SRp75 also known as serine/arginine-rich splicing factor 4, SR splicing factor 4, Pre-mRNA-splicing factor SRP75 & has been validated in WB.
      Key Applications
      • Western Blotting
      Application NotesImmunoprecipitation Analysis: A reprentative lot of this antibody was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human SRp75.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq].
      Gene Symbol
      • SRP001LB
      • SRP75
      • SFRS4
      • SRSF4
      Purification MethodProtein A
      UniProt Number
      UniProt SummaryFUNCTION: A probable role in alternative splice site selection during pre-mRNA splicing.

      SUBUNIT STRUCTURE: Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN.

      SUBCELLULAR LOCATION: Nucleus speckle

      PTM: Extensively phosphorylated on serine residues in the RS domain.

      SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.

      Contains 2 RRM (RNA recognition motif) domains.
      Molecular Weight ~ 62 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in L6 cell lysate.

      Western Blot Analysis: 1:500 dilution of this antibody detected SRp75 on 10 µg of L6 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SRp75 - 2115670 2115670
      Anti-SRp75 - 2361928 2361928
      Anti-SRp75 - 2561719 2561719
      Anti-SRp75 - 2999523 2999523
      Anti-SRp75 - NRG1852670 NRG1852670
      Anti-SRp75 -2652002 2652002
      Anti-SRp75 -2665774 2665774
      Anti-SRp75 -2821654 2821654
      Anti-SRp75_2849474 2849474

      References

      Reference overviewPub Med ID
      Detained introns are a novel, widespread class of post-transcriptionally spliced introns.
      Boutz, PL; Bhutkar, A; Sharp, PA
      Genes & development  29  63-80  2015

      Show Abstract
      25561496 25561496