04-453 | Anti-SUMO-1 Antibody, rabbit monoclonal

04-453
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WB, IH(P)RbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-453
      ReplacesAB3875; AB9186
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-SUMO-1 Antibody, rabbit monoclonal
      References
      Product Information
      FormatPurified
      PresentationIn 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-SUMO-1 Antibody, Rabbit is an antibody against SUMO-1 for use in IP, WB, IH(P).
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide composed of residues at the C-terminus of human SUMO-1.
      HostRabbit
      SpecificityRecognizes a region composed of residues at the C-terminus of human SUMO-1.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized.
      Gene Symbol
      • SUMO1
      • OFC10
      • DAP-1
      • sentrin
      • PIC1
      • SUMO-1
      • Sentrin
      • UBL1
      • SENP2
      • SMT3H3
      • SMT3
      • GMP1
      • SMT3C
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P63165 # Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1- SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.
      SIZE: 101 amino acids; 11557 Da
      SUBUNIT: Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2. Interacts with PARK2. Covalently attached to a number of proteins such as PML, RANGAP1, HIPK2, SP100, p53, p73-alpha, MDM2, JUN, DNMT3B and TDG. Also interacts with HIF1A, HIPK2, HIPK3, CHD3, EXOSC9, RAD51 and RAD52.
      SUBCELLULAR LOCATION: Nucleus membrane. Nucleus speckle. Cytoplasm.
      PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
      SIMILARITY: SwissProt: P63165 ## Belongs to the ubiquitin family. SUMO subfamily. & Contains 1 ubiquitin-like domain.
      Molecular Weight18/90 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-SUMO-1 (Rabbit monoclonal IgG) - 2426448 2426448
      Anti-SUMO-1 (Rabbit monoclonal IgG) - 2068517 2068517
      Anti-SUMO-1 (Rabbit monoclonal IgG) - 2341890 2341890
      Anti-SUMO-1 (Rabbit monoclonal IgG) - DAM1479620 DAM1479620
      Anti-SUMO-1 - DAM1541151 DAM1541151
      Anti-SUMO-1 - DAM1588279 DAM1588279
      Anti-SUMO-1 - DAM1782849 DAM1782849
      Anti-SUMO-1 -2515116 2515116
      Anti-SUMO-1, Rabbit Monoclonal - 0611046357 0611046357
      Anti-SUMO-1, Rabbit Monoclonal - JBC1371306 JBC1371306

      References

      Reference overviewApplicationPub Med ID
      Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells.
      Wang, C; Tao, W; Ni, S; Chen, Q; Zhao, Z; Ma, L; Fu, Y; Jiao, Z
      Cancer science  106  375-82  2015

      Show Abstract
      25645686 25645686
      Tax posttranslational modifications and interaction with calreticulin in MT-2 cells and human peripheral blood mononuclear cells of human T cell lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis patients.
      Medina, F; Quintremil, S; Alberti, C; Barriga, A; Cartier, L; Puente, J; Ramírez, E; Ferreira, A; Tanaka, Y; Valenzuela, MA
      AIDS research and human retroviruses  30  370-9  2014

      Show Abstract
      Western Blotting24321043 24321043
      Ubiquitin and its kin: how close are the family ties?
      Jentsch, S and Pyrowolakis, G
      Trends Cell Biol., 10: 335-42 (2000)  2000

      Show Abstract
      10884686 10884686

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies