MABE585 | Anti-SUN2, clone EPR6557, Rabbit Monoclonal Antibody

MABE585
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbUnpurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE585
      DescriptionAnti-SUN2, clone EPR6557, Rabbit Monoclonal Antibody
      Alternate Names
      • SUN domain-containing protein 2
      • Protein unc-84 homolog B
      • Rab5-interacting protein
      • Rab5IP
      • Sad1/unc-84 protein-like 2
      Background InformationSUN domain-containing protein 2 (SUN2), or Protein UNC-84 homolog B (UNC84B), is a single-pass nuclear envelope transmembrane protein responsible for nuclear migrations that are essential for development. SUN2 has a predicted transmembrane domain and a C-terminal region with similarity to the S. pombe spindle pole body protein Sad1. SUN2 interacts with RAB5A and is widely expressed, and highly expressed in the heart, lungs and muscles. UNC-84 may function to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage.
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Applications
      ApplicationThis Anti-SUN2, clone EPR6557, Rabbit Monoclonal Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of SUN2.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:250-500 dilution from a representative lot detected SUN2 in human lung tissue.

      Immunohistochemistry Analysis: A 1:250-500 dilution from a representative lot detected SUN2 in human ovarian tissue.

      Produced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to the C-terminus of human SUN2.
      EpitopeC-terminus
      CloneEPR6557
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • SUN2
      • FRIGG
      • KIAA0668
      • RAB5IP
      • UNC84B
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~80 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human fetal muscle, Saos-2, HeLa, Jurkat, and HepG2 lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected SUN2 in human fetal muscle, Saos-2, HeLa, Jurkat, and HepG2 lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies