CBL304 | Anti-Serum Amyloid P Antibody, clone 5.4A

CBL304
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL304
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Serum Amyloid P Antibody, clone 5.4A
      Alternate Names
      • Component P
      Background InformationAmyloid consists mainly of rigid, non-branching protein fibrils, together with rod-like aggregates of a pentagonal-shaped glycoprotein called amyloid P protein. Amyloid P protein, also known as component P, comprises 10 per cent of amyloid tissue and is present in all but the central nervous system forms of amyloid. Amyloid P protein is a constituent of normal basement membranes and the microfibrillaryelastic fiber network.
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100ug in phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationAnti-Serum Amyloid P Antibody, clone 5.4A detects level of Serum Amyloid P & has been published & validated for use in ELISA.
      Key Applications
      • ELISA
      Application NotesDevelopment of ELISA assay for the estimation of human serum amyloid P using CBL 305 biotin conjugate as the labelled pair

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHuman serum amyloid P
      Clone5.4A
      HostMouse
      SpecificityThis antibody is specific for human serum amyloid P.

      FUSION PARTNER: NS1 myeloma cell line
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.
      Gene Symbol
      • SAP
      • SAMP
      • APCS
      • PTX2
      UniProt Number
      UniProt SummaryFUNCTION: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
      COFACTOR: Binds 2 calcium ions per subunit.
      SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Found in serum and urine.
      PTM: N-glycosylated with a complex biantennary oligosaccharide chain with a sialic acid at the end (disialo-SAP). Monosialo-SAP as well as asioalo-SAP are also detected.
      DISEASE: SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
      SIMILARITY: Belongs to the pentaxin family.
      SIMILARITY: Contains 1 pentaxin domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN SERUM AMYLOID P -2803226 2803226
      MOUSE ANTI-HUMAN SERUM AMYLOID P -2817245 2817245
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY 2966315
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY 2988110
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY - 2165802 2165802
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY - 2283774 2283774
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY - 2302147 2302147
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY - 2309014 2309014
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY - 2310353 2310353
      MOUSE ANTI-HUMAN SERUM AMYLOID P PROTEIN MONOCLONAL ANTIBODY - 2352364 2352364

      References

      Reference overviewPub Med ID
      Serum amyloid P component prevents high-density lipoprotein-mediated neutralization of lipopolysaccharide.
      de Haas, C J, et al.
      Infect. Immun., 68: 4954-60 (2000)  2000

      Show Abstract
      10948110 10948110
      A synthetic lipopolysaccharide-binding peptide based on amino acids 27-39 of serum amyloid P component inhibits lipopolysaccharide-induced responses in human blood.
      de Haas, C J, et al.
      J. Immunol., 161: 3607-15 (1998)  1998

      Show Abstract
      9759883 9759883

      Data Sheet

      Title
      Anti-Amyloid P Protein, clone 5.4A - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies