06-650 | Anti-StIP-1 Antibody

06-650
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-650
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-StIP-1 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide with 30% glycerol
      Applications
      ApplicationAnti-StIP-1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of StIP-1 & has been validated in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide (C-SPDSKYFFTGSRDKK) corresponding to amino acids 678-692 of human StIP-1 (aka STATIP1), with an n-terminal cysteine added for conjugation purposes
      HostRabbit
      SpecificityStIP-1
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ELP2
      • SHINC-2
      • StIP
      • STATIP1
      • FLJ10879
      • StIP1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q6IA86 # Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
      SIZE: 826 amino acids; 92500 Da
      SUBUNIT: Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with STAT3 and JAKs (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      SIMILARITY: SwissProt: Q6IA86 ## Belongs to the WD repeat ELP2 family. & Contains 14 WD repeats.
      Molecular Weight92 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from murine BAF-3 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-StIP-1 (rabbit polyclonal IgG) - 2116120 2116120
      Anti-StIP-1 - 17528 17528

      References

      Reference overviewPub Med ID
      Purification and characterization of the human elongator complex.
      Hawkes, Nicola A, et al.
      J. Biol. Chem., 277: 3047-52 (2002)  2002

      Show Abstract
      11714725 11714725
      A Stat3-interacting protein (StIP1) regulates cytokine signal transduction.
      Collum, R G, et al.
      Proc. Natl. Acad. Sci. U.S.A., 97: 10120-5 (2000)  2000

      Show Abstract
      10954736 10954736