07-1803 | Anti-TAF4 Antibody

07-1803
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1803
      DescriptionAnti-TAF4 Antibody
      Alternate Names
      • Transcription initiation factor TFIID subunit 4
      • RNA polymerase II TBP-associated factor subunit C
      • TBP-associated factor 4
      • Transcription initiation factor TFIID 130 kDa subunit
      • TAF(II)130
      • TAFII-130
      • TAFII130
      • Transcription initiation factor TFIID 135 kDa subunit
      • TAF(II)135
      • TAFII-135
      • TAFII135
      Background InformationTAF4 (TBP-associated factor 4) is necessary for modulation of transcriptional activity and for activating the retinoic acid receptor and CREB. TAF4 function is thought to be regulated by the alternative TAF4 isoforms. Co-localization of TAF4 and RanBPM has been found to be important in neuronal differentiation. TAF4 has also been associated with TFIID and is thought to be responsible for the TFIID complex stability.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HepG2 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-TAF4 Antibody detects level of TAF4 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenLinear Peptide corresponding to human TAF4.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryInitiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq].
      Gene Symbol
      • TAF4
      • TAF2C
      • TAF2C1
      • TAF4A
      • TAFII130
      • TAFII135
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Makes part of TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone.

      SUBUNIT STRUCTURE: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts with SV40 Large T antigen.

      SUBCELLULAR LOCATION: Nucleus.

      SEQUENCE SIMILARITIES: Belongs to the TAF4 family.

      Contains 1 TAFH (NHR1) domain.
      Molecular Weight~ 110 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HepG2 cell lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected TAF4 on 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications