Key Spec Table
|Species Reactivity||Key Applications||Host||Format||Antibody Type|
|H, M, Ca, Ch||WB, IP||Rb||Culture Supernatant||Monoclonal Antibody|
|Presentation||Cultured supernatant containing 0.05% sodium azide.|
|Safety Information according to GHS|
|Material Size||100 µL|
|Anti-TBK1, clone AOW9||2882715|
|Anti-TBK1, clone AOW9 - 2211945||2211945|
|Anti-TBK1, clone AOW9 - 2561064||2561064|
|Anti-TBK1, clone AOW9 - NG1664793||NG1664793|
|Anti-TBK1, clone AOW9 - NG1752499||NG1752499|
|Anti-TBK1, clone AOW9 - NG1809711||NG1809711|
|Anti-TBK1, clone AOW9 - NG1852108||NG1852108|
|Anti-TBK1, clone AOW9 - NG1895102||NG1895102|
|Anti-TBK1, clone AOW9 -2594360||2594360|
|Anti-TBK1, clone AOW9 -2793453||2793453|
|Reference overview||Pub Med ID|
|IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.|
Fitzgerald, Katherine A, et al.
Nat. Immunol., 4: 491-6 (2003) 2003
The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activation of IRF3 and NF-kappaB. Activation of IRF3 requires signal-dependent phosphorylation, but little is known about the signaling pathway or kinases involved. Here we report that the noncanonical IkappaB kinase homologs, IkappaB kinase-epsilon (IKKepsilon) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-kappaB activation, are also essential components of the IRF3 signaling pathway. Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response.
|Triggering the interferon antiviral response through an IKK-related pathway.|
Sharma, Sonia, et al.
Science, 300: 1148-51 (2003) 2003
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor kappaB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IkappaB kinase (IKK)-related kinases IKKepsilon and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.