05-954 | Anti-TCL1 Antibody

05-954
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue Number05-954
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-TCL1 Antibody
      References
      Product Information
      FormatCulture Supernatant
      Applications
      ApplicationThis Anti-TCL1 Antibody is validated for use in WB, IH for the detection of TCL1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide corresponding to amino acids 60-73 (RPMTPTQIGPSLLP) of human TCL1A
      HostMouse
      SpecificityTCL1A, no cross-reactivity with TML1 (TCL1B) or MTCP1
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TCL1A
      • TCL1
      • TCL1-PEN
      Purification MethodCell culture supernatant
      UniProt Number
      UniProt SummarySIZE: 114 amino acids; 13460 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Microsome. Note=Microsomal fraction.
      TISSUE SPECIFICITY: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
      DISEASE: SwissProt: P56279 # Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta locuses.
      SIMILARITY: SwissProt: P56279 ## Belongs to the TCL1 family.
      Molecular Weight14 kD
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot in RIPA lysates from Raji cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TCL1 (mouse monoclonal culture supernatant) 2970623
      Anti-TCL1 (mouse monoclonal culture supernatant) -2496212 2496212
      Anti-TCL1 - 30600 30600
      Anti-TCL1 -2770474 2770474

      References

      Reference overviewPub Med ID
      Risk factors in thyroid-type carcinoma arising in ovarian struma: a report of 15 cases with comparison to ordinary struma ovarii.
      Roth LM, Talerman A, Wadsley J, Karseladze AI
      Histopathology  57  148-52.  2010

      20653787 20653787
      TCL1 is a diagnostic marker for intratubular germ cell neoplasia and classic seminoma.
      Dengfeng Cao,Zhaoli Lane,Robert William Allan,Peng Wang,Charles Chuanhai Guo,Yan Peng,Jianping Li
      Histopathology  57  2010

      20553335 20553335
      Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.
      Auguin, Daniel, et al.
      J. Biol. Chem., 279: 35890-902 (2004)  2004

      Show Abstract
      15169787 15169787
      A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories
      Herling, M. <i>et al.</i>
      Blood, 104:328-35 (2004)  2004

      15044256 15044256
      TCL1: a new drug target in lymphoid and germ-cell malignancies?
      Lock, Richard B
      Int. J. Biochem. Cell Biol., 35: 1614-8 (2003)  2003

      Show Abstract
      12962701 12962701
      Crystal structures of Tcl1 family oncoproteins and their conserved surface features.
      Petock, John M, et al.
      ScientificWorldJournal, 2: 1876-84 (2002)  2002

      Show Abstract
      12920316 12920316

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies