06-006 | Anti-TLR1 Antibody, CT

06-006
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-006
      DescriptionAnti-TLR1 Antibody, CT
      Alternate Names
      • CD281 antigen
      • Toll/interleukin-1 receptor-like
      • Toll/interleukin-1 receptor-like protein
      • toll-like receptor 1
      Background InformationThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR1 recognizes peptidoglycan and (triacyl) lipoproteins on pathogens, especially gram-positive bacteria. TLR1 is found on the surface of macrophages and neutrophils.
      References
      Product Information
      FormatPurified
      Control
      • Raji cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.
      Applications
      ApplicationDetect TLR1 using this Anti-TLR1 Antibody, C-terminus validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corres-ponding to the C-terminal region of TLR1.
      EpitopeC-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminal domain of TLR1.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq].
      Gene Symbol
      • CD281
      • DKFZp547I0610
      • DKFZp564I0682
      • KIAA0012
      • MGC104956
      • MGC126311
      • MGC126312
      • TIL
      • rsc786
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.

      SUBUNIT STRUCTURE:Binds MYD88 via their respective TIR domains By similarity. Interacts with TLR2 via its extracellular domain. Ligand binding induces the formation of a heterodimer with TLR2.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane proteinBy similarity. Cytoplasmic vesicle › phagosome membrane; Single-pass type I membrane proteinBy similarity.

      TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

      SIMILARITY: Belongs to the Toll-like receptor family.

      Contains 8 LRR (leucine-rich) repeats.

      Contains 1 TIR domain.

      Molecular Weight~90 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by western blot on Raji cell lysate.

      Western Blot Analysis:
      1 μg/mL of this antibody was used to detect TLR1 in Raji cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications