06-1119 | Anti-TLR2 Antibody

06-1119
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, Chp, Rhesus MacaqueWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1119
      DescriptionAnti-TLR2 Antibody
      Alternate Names
      • toll-like receptor 2
      • Toll/interleukin-1 receptor-like protein 4
      • toll/interleukin 1 receptor-like 4
      • CD282 antigen
      Background InformationToll-like receptor 2 (TLR2) is a single-pass type I membrane protein belonging to the Toll-like receptor family and is comprised of 14 LRR repeats and a single TIR domain. TLR2 interacts with LY96 or TLR1 to regulate innate immune response to bacterial lipoproteins and other components of the microbial cell wall. It induces the activation of NFκB, inflammatory response and cytokine secretion through interactions with MYD88 and TRAF6. It may also function as a promoter for apoptosis. High expression of TLR2 has been reported in blood leukocytes, specifically in bone marrow, lymph node, monocytes and spleen. It has also been observed in fetal liver and lung tissues. Modifications in gene expression have been implicated in an increased susceptibility to leprosy.
      References
      Product Information
      FormatAffinity Purified
      Control
      • RAW264.7 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-TLR2 Antibody is an antibody against TLR2 for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a previous lot detected TLR2 in normal human placenta tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the extracellular domain of human TLR2.
      EpitopeExtracellular Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the extracellular domain of TLR2.
      Species Reactivity
      • Mouse
      • Human
      • Chimpanzee
      • Rhesus Macaque
      Species Reactivity NoteDemonstrated to react with human and mouse.
      Predicted to react with chimpanzee and rhesus macaque based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq].
      Gene Symbol
      • TLR2
      • TIL4
      • CD282
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

      SIZE: 784 amino acids; 89838 Da

      SUBUNIT: Binds LY96 and TLR6 via the extracellular domain. Binds MYD88 via their respective TIR domains.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).

      TISSUE SPECIFICITY: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

      PTM: Glycosylation of Asn-442 is critical for secretion of the N- terminal ectodomain of TLR2.

      SIMILARITY: Belongs to the Toll-like receptor family. & Contains 14 LRR (leucine-rich) repeats. & Contains 1 TIR domain. ...
      Molecular Weight~90 kDa observed.
      Blocking without Tween is recommended to avoid the observance of additional bands.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in RAW264.7 cell lysate.

      Western Blot Analysis: 2 µg/mL of this antibody detected TLR2 in 10 µg of RAW264.7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TLR2 - 2360591 2360591
      Anti-TLR2 - 2420515 2420515
      Anti-TLR2 - 1953014 1953014
      Anti-TLR2 - 2075141 2075141
      Anti-TLR2 - 2197238 2197238
      Anti-TLR2 - 2262700 2262700
      Anti-TLR2 - NG1897884 NG1897884
      Anti-TLR2 - NG1924135 NG1924135
      Anti-TLR2 - NRG1806878 NRG1806878
      Anti-TLR2 -2504883 2504883

      References

      Reference overviewPub Med ID
      TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer.
      Proença, MA; de Oliveira, JG; Cadamuro, AC; Succi, M; Netinho, JG; Goloni-Bertolo, EM; Pavarino, ÉC; Silva, AE
      World journal of gastroenterology  21  7730-41  2015

      Show Abstract
      26167073 26167073
      Effect of Helicobacter pylori eradication on TLR2 and TLR4 expression in patients with gastric lesions.
      Cadamuro, AC; Rossi, AF; Matos Biselli-Périco, J; Fucuta Pereira, P; Do Vale, EP; Acayaba, R; Leite, KR; Goloni-Bertollo, EM; Silva, AE
      Mediators of inflammation  2015  481972  2015

      Show Abstract
      25873761 25873761
      Laminin forms an independent network in basement membranes.
      P D Yurchenco,Y S Cheng,H Colognato
      The Journal of cell biology  117  1992

      Show Abstract Full Text Article
      1577869 1577869

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies