06-1026 | Anti-TM7SF2 Antibody

06-1026
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, B, Rhesus MacaqueWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1026
      DescriptionAnti-TM7SF2 Antibody
      Alternate Names
      • Delta(14)-sterol reductase
      • Delta-14-SR
      • Another new gene 1 protein
      • C-14 sterol reductase
      • Putative sterol reductase SR-1
      • Sterol C14-reductase
      • Transmembrane 7 superfamily member 2
      Background InformationSterol Delta-14 reductase, also known as TM7SF2 and NET47, is important in the conversion of lanosterol to cholesterol, an essential cellular metabolic process, in many mammalian species. This protein is a multipass membrane protein typically found in the endoplasmic reticulum.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-TM7SF2 Antibody is a Rabbit Polyclonal Antibody for detection of TM7SF2 also known as Delta(14)-sterol reductase, Putative sterol reductase SR-1 & has been validated in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A representative lot was used by an independent laboratory in HeLa cells. (Image courtesy of Dr. Eric C. Schirmer, The Wellcome Trust Centre for Cell Biology, University of Edinburgh)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human TM7SF2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Bovine
      • Rhesus Macaque
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with bovine and rhesus monkey based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TM7SF2
      • ANG1
      • NET47
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Involved in the conversion of lanosterol to cholesterol.

      CATALYTIC ACTIVITY: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NADP+ = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol + NADPH.

      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein

      TISSUE SPECIFICTY: Expressed in adult heart, brain, pancreas, lung, liver, skeletal muscle, kidney, ovary, prostate, and testis, but not detected in placenta, spleen, thymus, small intestine, colon (mucosal lining), or peripheral blood leukocytes.

      SEQUENCE SIMILARITIES: Belongs to the ERG4/ERG24 family.

      SEQUENCE CAUTION: The sequence AAC21450.1 differs from that shown. Reason: Sequencing errors.

      The sequence AAC21457.1 differs from that shown. Reason: Sequencing errors.
      Molecular Weight~50 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human brain tissue lysate.

      Western Blot Analysis: 5 µg/mL of this antibody detected TM7SF2 on 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TM7SF2 - NRG1856985 NRG1856985
      Anti-TM7SF2 -2702105 2702105

      References

      Reference overviewPub Med ID
      Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.
      Zuleger, N; Boyle, S; Kelly, DA; de las Heras, JI; Lazou, V; Korfali, N; Batrakou, DG; Randles, KN; Morris, GE; Harrison, DJ; Bickmore, WA; Schirmer, EC
      Genome biology  14  R14  2013

      Show Abstract
      23414781 23414781