06-1037 | Anti-TMEM126A Antibody

06-1037
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1037
      DescriptionAnti-TMEM126A Antibody
      Alternate Names
      • transmembrane protein 126A
      Background InformationTransmembrane protein 126A (TMEM126A) is thought to be localized in the mitochondria however, the function is unknown. TMEM126A has been associated with mitochondrial dysfunction and nonsyndromic autosomal-recessive optic neuropathies.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human liver tissue lysate.
      Presentation0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
      Applications
      ApplicationUse Anti-TMEM126A Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC, IHC to detect TMEM126A also known as transmembrane protein 126A.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunocytochemistry Analysis: A representative lot of this antibody was used by an independent laboratory in IC. (Korfali, N., et al. (2010). Mol Cell Proteomics. 9:2571-2585.)

      Immunohistochemistry Analysis: A representative lot of this antibody was used by an independent laboratory in IH. (Korfali, N., et al. (2010). Mol Cell Proteomics. 9:2571-2585.)
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human TMEM126A.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TMEM126A
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummarySUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (potential). Mitochondrion.

      TISSUE SPECIFICITY: Strongly expressed in brain, cerebellum, skeletal muscle, testis. High expression also found in fetal brain, fetal retinal pigmentary epithelium, and fetal retina.

      INVOLVEMENT IN DISEASE: Defects in TMEM126A are the cause of optic atrophy type 7 (OPA7) [MIM:612989]. A hereditary condition that features progressive visual loss in association with optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. OPA7 is an autosomal recessive juvenile-onset optic atrophy characterized by severe bilateral deficiency in visual acuity, optic disk pallor, and central scotoma.

      SEQUENCE SIMILARITIES: Belongs to the TMEM126 family.
      Molecular Weight~23 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human liver tissue lysate.

      Western Blot Analysis: 0.125 µg/mL of this antibody detected TMEM126A on 10 µg of human liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TMEM126A - NRG1856987 NRG1856987

      References

      Reference overviewApplicationPub Med ID
      The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture.
      Korfali, N; Wilkie, GS; Swanson, SK; Srsen, V; Batrakou, DG; Fairley, EA; Malik, P; Zuleger, N; Goncharevich, A; de Las Heras, J; Kelly, DA; Kerr, AR; Florens, L; Schirmer, EC
      Molecular & cellular proteomics : MCP  9  2571-85  2010

      Show Abstract
      Western Blotting20693407 20693407
      Involvement of 70-kD heat-shock proteins in peroxisomal import.
      P A Walton,M Wendland,S Subramani,R A Rachubinski,W J Welch
      The Journal of cell biology  125  1994

      Show Abstract Full Text Article
      8195287 8195287