05-473 | Anti-TRADD Antibody, clone 3E11

05-473
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-473
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-TRADD Antibody, clone 3E11
      References
      Product Information
      FormatPurified
      PresentationLyophilized powder
      Applications
      ApplicationAnti-TRADD Antibody, clone 3E11 is an antibody against TRADD for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to full length (residues 1-312) human TRADD
      Clone3E11
      HostMouse
      SpecificityTRADD
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.
      Gene Symbol
      • TRADD
      • MGC11078
      • Hs.89862
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15628 # Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.
      SIZE: 312 amino acids; 34247 Da
      SUBUNIT: Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.
      SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
      TISSUE SPECIFICITY: Found in all examined tissues.
      DOMAIN:SwissProt: Q15628 Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1.
      SIMILARITY: Contains 1 death domain.
      Molecular Weight34kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from A431 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: 2 years at 4°C; Rehydrated: 3 months at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-TRADD, clone 3E11 - 16752 16752
      Anti-TRADD, clone 3E11 - 21759 21759
      Anti-TRADD, clone 3E11 - 26281 26281
      Anti-TRADD, clone 3E11 - 28068 28068

      References

      Reference overviewPub Med ID
      Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.
      Varfolomeev, E; Maecker, H; Sharp, D; Lawrence, D; Renz, M; Vucic, D; Ashkenazi, A
      The Journal of biological chemistry  280  40599-608  2005

      Show Abstract
      16227629 16227629
      Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
      Boldin, M P, et al.
      Cell, 85: 803-15 (1996)  1996

      Show Abstract
      8681376 8681376
      Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins.
      Takeuchi, M, et al.
      J. Biol. Chem., 271: 19935-42 (1996)  1996

      Show Abstract
      8702708 8702708
      TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.
      Hsu, H, et al.
      Cell, 84: 299-308 (1996)  1996

      Show Abstract
      8565075 8565075
      Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD.
      Park, A and Baichwal, V R
      J. Biol. Chem., 271: 9858-62 (1996)  1996

      Show Abstract
      8621670 8621670
      The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.
      Hsu, H, et al.
      Cell, 81: 495-504 (1995)  1995

      Show Abstract
      7758105 7758105

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies