04-451 | Anti-TRAF6 Antibody, rabbit monoclonal

04-451
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P)RbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-451
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-TRAF6 Antibody, rabbit monoclonal
      Background InformationTNF receptor-associated factor 6 is a member of the TNF receptor associated factor (TRAF) protein family. TNF receptor-associated factor 6 proteins play an important role as adaptor protein for cell survival, proliferation, differentiation and stress responses. TNF receptor-associated factor 6 has unique binding behavior that result in signaling responses from the interleukin-1 receptor (IL-1R) toll-like receptor. TNF receptor-associated factor 6 mediates signaling indirectly with IL-1R/TLR through IRAK. This leads to activation of NF-κB and MAP kinase signaling pathways though downstream association with the TAB/TAK-1 complex. TNF receptor-associated factor 6 is also involved in the activation of Akt/PKB and serves as a direct E3 ligase which is essential for Akt ubiquitination.
      References
      Product Information
      FormatPurified
      PresentationIn 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-TRAF6 Antibody, Rabbit detects level of TRAF6 & has been published & validated for use in WB, IH(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide composed of residues at the N-terminus of human TRAF6.
      HostRabbit
      SpecificityRecognizes a region composed of residues at the N-terminus of human TRAF6.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported.
      Gene Symbol
      • TRAF6
      • RNF85
      • MGC:3310
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y4K3 # Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Also involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. Seems to be involved in IL-17 signaling (By similarity). Mediates activation of NF-kappa-B and JNK. May function as an E3 ubiquitin ligase.
      SIZE: 522 amino acids; 59573 Da
      SUBUNIT: Homotrimer (Probable). Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, and TRAF- interacting protein TRIP and TRAF and TNF receptor associated protein TTRAP. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675.
      SUBCELLULAR LOCATION: Cytoplasm (Probable).TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.DOMAIN:SwissProt: Q9Y4K3 The coiled coil domain mediates homo- and hetero- oligomerization. & The MATH/TRAF domain binds to receptor cytoplasmic domains.
      PTM: Polyubiquitinated (By similarity).
      SIMILARITY: Contains 1 MATH domain. & Contains 1 RING-type zinc finger. & Contains 2 TRAF-type zinc fingers.
      Molecular Weight58 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TRAF6 (Rabbit monoclonal IgG) - 2119996 2119996
      Anti-TRAF6 (Rabbit monoclonal IgG) - 2274013 2274013
      Anti-TRAF6 (Rabbit monoclonal IgG) - DAM1411351 DAM1411351
      Anti-TRAF6 (Rabbit monoclonal IgG) - DAM1528113 DAM1528113
      Anti-TRAF6 (Rabbit monoclonal IgG) - JBC1371305 JBC1371305
      Anti-TRAF6 (Rabbit monoclonal IgG) - NG1899890 NG1899890
      Anti-TRAF6 - 1983667 1983667
      Anti-TRAF6 - DAM1557513 DAM1557513
      Anti-TRAF6 - DAM1597405 DAM1597405
      Anti-TRAF6 - DAM1612209 DAM1612209

      References

      Reference overviewPub Med ID
      The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF- κ B Pathway in Mice.
      Chen, L; Yan, X; Yan, Q; Fan, J; Huang, H; Shi, X; Han, L; Han, T; Zhu, H
      Evidence-based complementary and alternative medicine : eCAM  2015  790739  2015

      Show Abstract
      26089947 26089947
      Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling.
      Valente, AJ; Yoshida, T; Clark, RA; Delafontaine, P; Siebenlist, U; Chandrasekar, B
      Free radical biology & medicine  60  125-35  2013

      Show Abstract
      23453926 23453926
      The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
      Wong, B R, et al.
      J. Biol. Chem., 273: 28355-9 (1998)  1998

      Show Abstract
      9774460 9774460
      Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
      Ishida, T, et al
      J Biol Chem, 271:28745-8 (1996)  1996

      8910514 8910514

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies