06-1005 | Anti-TRIC-A Antibody

06-1005
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, M, ChpWB, IHC, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1005
      DescriptionAnti-TRIC-A Antibody
      Alternate Names
      • transmembrane protein 38A
      • trimeric intracellular cation channel type A
      • Tmem38a
      • NET1
      Background InformationTRIC-A (trimeric intracellular cation channel type A), also known as Tmem38A, and sometimes NET1, is one of a number of TRIC channel subtypes that are believed to function as a Ca2+ counter-ion channel. TRIC-A is highly expressed in excitable cells and seems to work in coordination with Ca2+ release to balance transient negative potential. TRIC-A is located on the sarcoplasmic reticulum (SR) and is thought to be regulated by trans-membrane voltage. TRIC-A deficiency may lead to an abundance of Ca2+ and cause volatility in Ca2+ movement across the SR membrane.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human fetal skeletal muscle tissue lysate.
      PresentationPurified rabbit polyclonal in PBS containing 0.05% sodium azide.
      Applications
      ApplicationAnti-TRIC-A Antibody detects level of TRIC-A & has been published & validated for use in WB, IH & IC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).

      Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRIC-A.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the cytoplasmic domain of TRIC-A.
      Species Reactivity
      • Human
      • Rat
      • Mouse
      • Chimpanzee
      Species Reactivity NoteDemonstrated to react with Human, Rat, and Mouse. Predicted to react with Chimpanzee based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TRIC-A
      • MGC3169
      • TRICA
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).

      SUBUNIT STRUCTURE: Homotrimer (By similarity).

      SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane (By similarity).

      DOMAIN: The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.

      SEQUENCE SIMILARITIES: Belongs to the TMEM38 family.
      Molecular Weight~33 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human fetal skeletal muscle tissue lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected TRIC-A on 10 µg of human fetal skeletal muscle tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TRIC-A ANTI-TRIC-A
      Anti-TRIC-A - NRG1901298 NRG1901298
      Anti-TRIC-A -2503020 2503020
      Anti-TRIC-A -2567117 2567117
      Anti-TRIC-A Polyclonal Antibody 2957914

      References

      Reference overviewApplicationPub Med ID
      Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations.
      Wilkie, GS; Korfali, N; Swanson, SK; Malik, P; Srsen, V; Batrakou, DG; de las Heras, J; Zuleger, N; Kerr, AR; Florens, L; Schirmer, EC
      Molecular & cellular proteomics : MCP  10  M110.003129  2011

      Show Abstract Full Text Article
      Western Blotting20876400 20876400

      Brochure

      Title
      New Products: Volume 3, 2012