04-427 | Anti-TSC2 Antibody, rabbit monoclonal

100 µL  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RFC, WB, IH(P)RbSemi-PurifiedMonoclonal Antibody
      Catalogue Number04-427
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-TSC2 Antibody, rabbit monoclonal
      Alternate Names
      • tuberous sclerosis 2
      • tuberin
      Product Information
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. This Anti-TSC2 Antibody, rabbit is validated for use in FC, WB, IH(P) for the detection of TSC2.
      Key Applications
      • Flow Cytometry
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the C-terminal region of human TSC2/Tuberin.
      EpitopeC-terminal domain
      SpecificityRecognizes the C-terminal domain of TSC2.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.
      Gene Symbol
      • TSC2
      • TSC4
      • FLJ43106
      • tuberin
      • LAM
      • Tuberin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49815 # Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 leads to constitutive activation of RAP1A in tumors.
      SIZE: 1807 amino acids; 200749 Da
      SUBUNIT: Interacts with TSC1. May also interact with the adapter molecule RABEP1. The final complex contains TSC2 and RABEP1 linked to RAB5 (Probable). Interacts with HSPA1 and HSPA8.
      SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
      TISSUE SPECIFICITY: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
      PTM: Phosphorylation at Ser-1387, Ser-1418 or Ser-1420 does not affect interaction with TSC1.
      DISEASE: SwissProt: P49815 # Defects in TSC2 are the cause of tuberous sclerosis complex (TSC) [MIM:191100]. The molecular basis of TSC is a functional impairment of the tuberin-hamartin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (developmental abnormalities of tissue combination). Clinical symptoms can range from benign hypopigmented macules of the skin to profound mental retardation with intractable seizures to premature death from a variety of disease-associated causes. & Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.
      SIMILARITY: SwissProt: P49815 ## Contains 1 Rap-GAP domain.
      Molecular Weight189 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-TSC2 (Rabbit monoclonal IgG) - 2109487 2109487
      Anti-TSC2 (Rabbit monoclonal IgG) - 2135057 2135057
      Anti-TSC2 (Rabbit monoclonal IgG) - 2426438 2426438
      Anti-TSC2 (Rabbit monoclonal IgG) - 2448415 2448415
      Anti-TSC2 (Rabbit monoclonal IgG) - 2460920 2460920
      Anti-TSC2 (Rabbit monoclonal IgG) - 1956696 1956696
      Anti-TSC2 (Rabbit monoclonal IgG) - DAM1442534 DAM1442534
      Anti-TSC2 - DAM1514041 DAM1514041
      Anti-TSC2 - DAM1548632 DAM1548632
      Anti-TSC2 - DAM1647892 DAM1647892


      Reference overviewPub Med ID
      Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis.
      Kwiatkowski, David J
      Cancer Biol. Ther., 2: 471-6 (2003)  2003

      Show Abstract
      14614311 14614311
      Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
      Garami, Attila, et al
      Mol Cell, 11:1457-66 (2003)  2003

      12820960 12820960

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      Life Science Research > Antibodies and Assays > Primary Antibodies