06-1301 | Anti-TTF2 Antibody

06-1301
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBShSerumPolyclonal Antibody
      Description
      Catalogue Number06-1301
      DescriptionAnti-TTF2 Antibody
      Alternate Names
      • Forkhead box protein E2
      • Forkhead-related protein FKHL15
      • HNF-3/fork head-like protein 5
      • Thyroid transcription factor 2
      • forkhead box E1
      • forkhead box E1 (thyroid transcription factor 2)
      • forkhead box E2
      • forkhead, drosophila, homolog-like 15
      Background InformationTranscription termination factor, RNA polymerase II, also known as TTF2, is a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. TTF2 has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. TTF2 can be found in the cytoplasm during interphase and relocates to the nucleus as the cell enters mitosis.
      References
      Product Information
      FormatSerum
      Control
      • Jurkat cell lysate
      PresentationSheep polyclonal serum containing 0.05% sodium azide.
      Applications
      ApplicationUse Anti-TTF2 Antibody (Sheep Polyclonal Antibody) validated in WB to detect TTF2 also known as Forkhead-related protein FKHL15, hyroid transcription factor 2.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHis-tagged recombinant protein corresponding to human TTF2.
      HostSheep
      SpecificityThis antibody recognizes TTF2.
      Species Reactivity
      • Human
      Species Reactivity NoteProven to react with human.
      Mouse and rat (70% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
      Gene Symbol
      • FKHL15
      • FOXE2
      • HFKH4
      • HFKL5
      • OTTHUMP00000021756
      • TITF2
      • TTF-2
      • TTF2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Probable transcription factor. Could be involved in thyroid gland organogenesis.
      SUBCELLULAR LOCATION: Nucleus Potential.
      TISSUE SPECIFICITY: Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.
      PTM: Phosphorylated By similarity.
      POLYMORPHISM: An alanine stretch that varies from 12 to 19 residues is present. This polymorphisms can be used as a marker to study the role of FOXE1 in other cases of thyroid dysgenesis, especially in familial cases.
      INVOLVEMENT IN DISEASE: Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome [MIM:241850]. A disease associated with thyroid agenesis, cleft palate and choanal atresia.
      SEQUENCE SIMILARITIES: Contains 1 fork-head DNA-binding domain.
      SEQUENCE CAUTION: The sequence CAA64246.1 differs from that shown. Reason: Miscellaneous discrepancy. Several conflicts.
      Molecular Weight~130 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Jurkat cell lysate.
      Western Blot Analysis: A 1:1,000 dilution of this antibody detected TTF2 in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies