05-385 | Anti-Talin (human) Antibody, clone TA205

05-385
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RbIP, WB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-385
      ReplacesCBL227
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Talin (human) Antibody, clone TA205
      References
      Product Information
      FormatPurified
      PresentationPBS, pH 7.4, 0.05% sodium azide
      Applications
      ApplicationAnti-Talin (human) Antibody, clone TA205 is an antibody against Talin (human) for use in IP, WB, IH.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenHuman Talin
      Cloneclone TA205
      HostMouse
      SpecificityTalin
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
      Gene Symbol
      • TLN1
      • KIAA1027
      • Talin-1.
      • ILWEQ
      • TLN
      • talin
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y490 # Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
      SIZE: 2541 amino acids; 269767 Da
      SUBUNIT: Binds with high affinity to vinculin and with low affinity to integrins. Interacts with PIP5K1C and NRAP. Interacts with LAYN.
      SUBCELLULAR LOCATION: Cell projection, ruffle membrane (By similarity). Note=Colocalizes with LAYN at the membrane ruffles (By similarity).
      SIMILARITY: SwissProt: Q9Y490 ## Contains 1 FERM domain. & Contains 1 I/LWEQ domain.
      Molecular Weight200kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on a human A431 RIPA cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Talin (human), clone TA205 (mouse monoclonal IgG1) - 2006036 2006036
      Anti-Talin (human), clone TA205 (mouse monoclonal IgG1) - 2273953 2273953
      Anti-Talin (human), clone TA205 (mouse monoclonal IgG1) - DAM1805222 DAM1805222
      Anti-Talin (human), clone TA205 - 15226 15226
      Anti-Talin (human), clone TA205 - 18022 18022
      Anti-Talin (human), clone TA205 - 19991 19991
      Anti-Talin (human), clone TA205 - 2524626 2524626
      Anti-Talin (human), clone TA205 - 26420 26420
      Anti-Talin (human), clone TA205 - 32133 32133
      Anti-Talin (human), clone TA205 - DAM1588202 DAM1588202

      References

      Reference overviewPub Med ID
      The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions.
      Wozniak, Michele A, et al.
      PeerJ, 1: e134 (2013)  2013

      Show Abstract
      24010014 24010014
      Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway.
      Kopecki, Z; O'Neill, GM; Arkell, RM; Cowin, AJ
      The Journal of investigative dermatology  131  1450-9  2011

      Show Abstract
      21430700 21430700
      Hsp72 interacts with paxillin and facilitates the reassembly of focal adhesions during recovery from ATP depletion.
      Mao, H; Wang, Y; Li, Z; Ruchalski, KL; Yu, X; Schwartz, JH; Borkan, SC
      The Journal of biological chemistry  279  15472-80  2004

      Show Abstract
      14718530 14718530
      HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells.
      Ruchalski, K; Mao, H; Singh, SK; Wang, Y; Mosser, DD; Li, F; Schwartz, JH; Borkan, SC
      American journal of physiology. Cell physiology  285  C1483-93  2003

      Show Abstract
      12930708 12930708
      Temperature dependent specific heat capacity (Cp) of G-actin and talin or talin-vinculin bound to G-actin.
      Goldmann, W H and Isenberg, G
      Biochem. Soc. Trans., 20: 273S (1992)  1992

      1426559 1426559

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies