06-561 | Anti-Tec Antibody

06-561
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-561
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Tec Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
      Applications
      ApplicationThis Anti-Tec Antibody is validated for use in IP, WB for the detection of Tec.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPeptide containing amino acid residues 165-182 of mouse Tec
      HostRabbit
      SpecificityTec
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.
      Gene Symbol
      • TEC
      • MGC126760
      • PSCTK4
      • MGC126762
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryCOFACTOR: Binds 1 zinc ion per subunit (By similarity).
      SIZE: 631 amino acids; 73581 Da
      SUBUNIT: Interacts with INPP5D/SHIP1 and INPPL1/SHIP2.
      SUBCELLULAR LOCATION: Cytoplasm (Probable).
      TISSUE SPECIFICITY: Hematopoietic cell lines including myeloid, B-, and T-cell lineages.
      SIMILARITY: SwissProt: P42680 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight66kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on mouse 3T3 cell lysate, CTLL, L6, Raji or Jurkat cell lysates
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Tec (rabbit polyclonal IgG) 2937096
      Anti-Tec (rabbit polyclonal IgG) 2872448
      Anti-Tec (rabbit polyclonal IgG) 2868376
      Anti-Tec (rabbit polyclonal IgG) 2876654
      Anti-Tec (rabbit polyclonal IgG) 2909175
      Anti-Tec (rabbit polyclonal IgG) - 2020909 2020909
      Anti-Tec (rabbit polyclonal IgG) - 2197504 2197504
      Anti-Tec (rabbit polyclonal IgG) - 2275583 2275583
      Anti-Tec (rabbit polyclonal IgG) - 2298161 2298161
      Anti-Tec (rabbit polyclonal IgG) - 2364203 2364203

      References

      Reference overviewApplicationPub Med ID
      Signaling through CD16b in human neutrophils involves the Tec family of tyrosine kinases.
      Fernandes, MJ; Lachance, G; Paré, G; Rollet-Labelle, E; Naccache, PH
      Journal of leukocyte biology  78  524-32  2005

      Show Abstract
      15899983 15899983
      Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases.
      Lachance, G; Levasseur, S; Naccache, PH
      The Journal of biological chemistry  277  21537-41  2002

      Show Abstract
      Immunoprecipitation11940595 11940595
      Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells.
      T B van Dijk, E van Den Akker, M P Amelsvoort, H Mano, B Löwenberg, M von Lindern
      Blood  96  3406-13  2000

      Show Abstract
      11071635 11071635
      Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding
      Tang, B, et al
      Mol Cell Biol, 14:8432-7 (1994)  1994

      7526158 7526158
      Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit
      Mano, H, et al
      Oncogene, 8:417-24 (1993)  1993

      7678927 7678927

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies