05-880 | Anti-Thrombin Antibody, clone GMA-020

05-880
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-880
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Thrombin Antibody, clone GMA-020
      References
      Product Information
      FormatPurified
      Applications
      ApplicationAnti-Thrombin Antibody, clone GMA-020 is an antibody against Thrombin for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpurified human thrombin
      CloneGMA-020
      HostMouse
      Specificitythrombin
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCoagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
      Gene Symbol
      • F2
      • prothrombin
      • PT
      Purification MethodDEAE purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P00734 # Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.
      SIZE: 622 amino acids; 70037 Da
      SUBCELLULAR LOCATION: Secreted, extracellular space.
      TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.
      PTM: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.
      DISEASE: SwissProt: P00734 # Defects in F2 are the cause of various forms of dysprothrombinemia [MIM:176930]. & Genetic variations in F2 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
      SIMILARITY: SwissProt: P00734 ## Belongs to the peptidase S1 family. & Contains 1 Gla (gamma-carboxy-glutamate) domain. & Contains 2 kringle domains. & Contains 1 peptidase S1 domain.
      MISCELLANEOUS: Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. & It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting. & Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa. & The cleavage after Arg-198, observed in vitro, does not occur in plasma.
      Molecular WeightMr 31kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on human thrombin
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Thrombin, clone GMA-020 2474824
      Anti-Thrombin, clone GMA-020 (mouse monoclonal IgG1) 2960505
      Anti-Thrombin, clone GMA-020 (mouse monoclonal IgG1) 2883132
      Anti-Thrombin, clone GMA-020 (mouse monoclonal IgG1) 2951478
      Anti-Thrombin, clone GMA-020 (mouse monoclonal IgG1) - 2283768 2283768
      Anti-Thrombin, clone GMA-020 - 27198 27198
      Anti-Thrombin, clone GMA-020 -2521589 2521589
      Anti-Thrombin, clone GMA-020 -2689035 2689035
      Anti-Thrombin, clone GMA-020 -2755731 2755731
      Anti-Thrombin, clone GMA-020 -2782556 2782556

      References

      Reference overviewPub Med ID
      A review of the therapeutic uses of thrombin.
      Lundblad, Roger L, et al.
      Thromb. Haemost., 91: 851-60 (2004)  2004

      Show Abstract
      15116244 15116244
      Bivalent direct thrombin inhibitors: hirudin and bivalirudin.
      Warkentin, Theodore E
      Best practice & research. Clinical haematology, 17: 105-25 (2004)  2004

      Show Abstract
      15171961 15171961
      The role of the tissue factor-thrombin pathway in cardiac ischemia-reperfusion injury.
      Mackman, Nigel
      Seminars in vascular medicine, 3: 193-8 (2003)  2003

      Show Abstract
      15199482 15199482
      Thrombin domains: structure, function and interaction with platelet receptors.
      De Cristofaro, Raimondo and De Candia, Erica
      J. Thromb. Thrombolysis, 15: 151-63 (2003)  2003

      Show Abstract
      14739624 14739624

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies