06-540 | Anti-Thyroid Hormone Receptor β-2 Antibody

06-540
250 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIHC, IP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-540
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Thyroid Hormone Receptor β-2 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4 with 0.05% sodium azide
      Applications
      ApplicationAnti-Thyroid Hormone Receptor β-2 Antibody is an antibody against Thyroid Hormone Receptor β-2 for use in IH, IP & WB.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide corresponding to amino acids 86-101 in rat TRβ-2
      HostRabbit
      SpecificityTRβ-2
      IsotypeIgG
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far.
      Gene Symbol
      • THRB
      • MGC126110
      • THR1
      • THRB1
      • GRTH
      • ERBA-BETA
      • ERBA2
      • MGC126109
      • NR1A2
      • THRB2
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P10828 # High affinity receptor for triiodothyronine.| P37243 # High affinity receptor for triiodothyronine.
      SIZE: 461 amino acids; 52788 Da
      SUBUNIT: Interacts with NOCA7 in a ligand-inducible manner.
      SUBCELLULAR LOCATION: Nucleus.
      DOMAIN: SwissProt: P10828 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
      DISEASE: SwissProt: P10828 # Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit- hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). & Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also called familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.| P37243 # Defects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit- hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). & Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also called familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
      SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.| P37243
      Molecular Weight60kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on rat pituitary extract
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Thyroid Hormone Receptor beta;-2 - 14823 14823

      References

      Reference overviewPub Med ID
      A rapid interference between glucocorticoids and cAMP-activated signaling in hypothalamic neurons prevents binding of pCREB and GR at the CRE-like and composite GRE sites of TRH gene promoter.
      Díaz-Gallardo MY, Cote-Vélez A, Charli JL, Joseph-Bravo P
      Journal of neuroendocrinology  2010

      Show Abstract
      20136691 20136691
      Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level.
      Perello, M; Cakir, I; Cyr, NE; Romero, A; Stuart, RC; Chiappini, F; Hollenberg, AN; Nillni, EA
      American journal of physiology. Endocrinology and metabolism  299  E976-89  2010

      Show Abstract
      20858755 20858755
      Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells.
      Keiko Nakano, Akio Matsushita, Shigekazu Sasaki, Hiroko Misawa, Kozo Nishiyama, Yumiko Kashiwabara, Hirotoshi Nakamura
      The Biochemical journal  378  549-57  2004

      Show Abstract Full Text Article
      14611644 14611644
      Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries.
      Yen, P M, et al.
      Endocrinology, 130: 1539-46 (1992)  1992

      Show Abstract
      1537303 1537303