06-1109 | Anti-Toll-Interacting Protein (TOLLIP) Antibody

06-1109
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, H, M, CaWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1109
      DescriptionAnti-Toll-Interacting Protein (TOLLIP) Antibody
      Alternate Names
      • toll interacting protein
      • Toll-interacting protein
      • adapter protein
      Background InformationToll-interacting protein (TOLLIP) is a novel protein belonging to the tollip family of proteins and is comprised of a C2 domain and a CUE domain. It is involved in the signaling pathways for Toll-like receptors and IL-1 receptor, and serves to inhibit microbial product induced cell activation. TOLLIP interacts with IRAK1, forming a complex with the IL-1 receptor in resting cells. It is also a substrate for IRAK1 phosphorylation.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Rat brain tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Toll-Interacting Protein (TOLLIP) Antibody is an antibody against Toll-Interacting Protein (TOLLIP) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C2 domain of human TOLLIP.
      EpitopeC2 domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C2 domain of TOLLIP.
      Species Reactivity
      • Rat
      • Human
      • Mouse
      • Canine
      Species Reactivity NoteDemonstrated to react with human, mouse and rat.
      Predicted to react with canine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. [supplied by RefSeq].
      Gene Symbol
      • TOLLIP
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.

      SUBUNIT STRUCTURE: Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. Interacts with TOM1L2.

      SUBCELLULAR LOCATION: Cytoplasm Probable.

      PTM: Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.

      SEQUENCE SIMILARITIES: Belongs to the tollip family.

      Contains 1 C2 domain.

      Contains 1 CUE domain.

      SEQUENCE CAUTIOIN: The sequence BAB14283.1 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight~32 kDa observed.
      A non specific band may appear at ~80 kDa with the use of Tween.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat brain tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected TOLLIP in 10 µg of rat brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Toll-Interacting Protein (TOLLIP) - NRG1777073 NRG1777073

      References

      Reference overviewPub Med ID
      Endoglin modulates cellular responses to TGF-beta 1.
      P Lastres,A Letamendía,H Zhang,C Rius,N Almendro,U Raab,L A López,C Langa,A Fabra,M Letarte,C Bernabéu
      The Journal of cell biology  133  1996

      Show Abstract Full Text Article
      8655583 8655583