06-1001 | Anti-Torsin-1A-interacting protein 1 Antibody

06-1001
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1001
      DescriptionAnti-Torsin-1A-interacting protein 1 Antibody
      Alternate Names
      • associated polypeptide 1B
      • lamina-associated polypeptide 1B
      • torsin A interacting protein 1
      Background InformationTorsin-1A-interacting protein 1, also known as lamina associated polypeptide 1B (LAP1B), is a protein encoded by the TOR1AIP1 gene. As suggested by its name, this protein interacts with torsin A and is implicated in the the disease torsion A dystonia. This protein is a type II integral membrane protein with a nuclear N-terminus and a single transmembrane domain. It is known to bind to A- and B-type lamins and has a possible role in membrane attachment and assembly of the nuclear lamina. A number of splice variants are known to exist.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-Torsin-1A-interacting protein 1 Antibody is a rabbit polyclonal antibody for detection of Torsin-1A-interacting protein 1 also known as associated polypeptide 1B, lamina-associated polypeptide 1B & has been validated in WB, ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blot (SNAP ID) Analysis:
      1 µg/ml of this antibody detected Torsin-1A-interacting protein 1 on 10 µg of HeLa cell lysate.

      Immunocytochemistry Analysis:
      1:500 dilution from a representative lot detected Torsin-1A-interacting protein 1 in HeLa and A431 cells.
      Biological Information
      ImmunogenKLH- Conjugated - Linear Peptide corresponding to the lumenal portion of human Torsin-1A-interacting protein 1.
      EpitopeLumenal
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Torsin-1A-interacting protein 1.
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human. Rat (75% sequence homology), Mouse (76% sequence homology)
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TOR1AIP1
      • LAP1B
      • MGC3413
      • FLJ13142
      • DKFZp586G011
      • RP11-533E19.1
      • TOR1AIP1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina By similarity.

      SUBUNIT STRUCTURE: Interacts with TOR1A.

      SUBCELLULAR LOCATION: Nucleus inner membrane; Single-pass membrane protein By similarity.

      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.

      SEQUENCE SIMILARITIES: Belongs to the TOR1AIP family.
      Molecular WeightThere are at least half a dozen splice variants, the primary band being at 67 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.5 µg/ml of this antibody detected Torsin-1A-interacting protein 1 on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications