06-471 | Anti-Transglutaminase type II Antibody

250 µL  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Gp, MIP, WBGtSerumPolyclonal Antibody
      Catalogue Number06-471
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Transglutaminase type II Antibody
      Product Information
      Presentationantiserum containing 0.05% sodium azide
      ApplicationThis Anti-Transglutaminase type II Antibody is validated for use in IP, WB for the detection of Transglutaminase type II.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPurified guinea pig liver type II transglutaminase
      Specificitytype II transglutaminase
      Species Reactivity
      • Guinea Pig
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryTransglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • TGM2
      • TG
      • protein-glutamine-gamma-glutamyltransferase
      • TGC
      • TG2
      • Transglutaminase-2
      • C
      • TGase-H
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P21980 # Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
      COFACTOR: Binds 1 calcium ion per subunit (By similarity).
      SIZE: 687 amino acids; 77329 Da
      SUBUNIT: Monomer.
      SIMILARITY: SwissProt: P21980 ## Belongs to the transglutaminase superfamily. Transglutaminase family.
      Molecular Weight78kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on murine liver tissue extracts, murine spleen, testes, thymus and kidney tissue extracts or purified enzyme from guinea pig liver
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size250 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Transglutaminase type II - 14527 14527
      Anti-Transglutaminase type II - 19065 19065
      Anti-Transglutaminase type II - 21090 21090
      Anti-Transglutaminase type II - 25990 25990
      Anti-Transglutaminase, type II (goat antiserum) - 2371134 2371134
      Anti-Transglutaminase, type II - DAM1641094 DAM1641094
      Anti-Transglutaminase, type II - DAM1749211 DAM1749211


      Reference overviewApplicationPub Med ID
      TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
      Delhase, M; Kim, SY; Lee, H; Naiki-Ito, A; Chen, Y; Ahn, ER; Murata, K; Kim, SJ; Lautsch, N; Kobayashi, KS; Shirai, T; Karin, M; Nakanishi, M
      Proceedings of the National Academy of Sciences of the United States of America  109  E177-86  2012

      Show Abstract
      22203995 22203995
      Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease.
      Robin Verhaar,Benjamin Drukarch,John G J M Bol,Cornelis A M Jongenelen,René J P Musters,Micha M M Wilhelmus
      Neurobiology of disease  45  2012

      Show Abstract
      22051113 22051113
      Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells.
      Khositseth, S; Pisitkun, T; Slentz, DH; Wang, G; Hoffert, JD; Knepper, MA; Yu, MJ
      Molecular & cellular proteomics : MCP  10  M110.004036  2011

      Show Abstract
      20940332 20940332
      Regulation of ATPase activity of transglutaminase 2 by MT1-MMP: implications for mineralization of MC3T3-E1 osteoblast cultures.
      Yukiko Nakano,Jennifer Forsprecher,Mari T Kaartinen
      Journal of cellular physiology  223  2010

      Show Abstract
      20049897 20049897
      Automated quantification tool for high-throughput proteomics using stable isotope labeling and LC-MSn.
      Guanghui Wang, Wells W Wu, Trairak Pisitkun, Jason D Hoffert, Mark A Knepper, Rong-Fong Shen, Guanghui Wang, Wells W Wu, Trairak Pisitkun, Jason D Hoffert, Mark A Knepper, Rong-Fong Shen
      Analytical chemistry  78  5752-61  2006

      Show Abstract
      16906720 16906720
      High-throughput identification of IMCD proteins using LC-MS/MS.
      Pisitkun, T; Bieniek, J; Tchapyjnikov, D; Wang, G; Wu, WW; Shen, RF; Knepper, MA
      Physiological genomics  25  263-76  2006

      Show Abstract
      16449382 16449382
      Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells.
      Szondy, Zsuzsa, et al.
      Proc. Natl. Acad. Sci. U.S.A., 100: 7812-7 (2003)  2003

      Show Abstract
      Immunoblotting (Western)12810961 12810961
      Targeted inactivation of Gh/tissue transglutaminase II.
      Nanda, N; Iismaa, SE; Owens, WA; Husain, A; Mackay, F; Graham, RM
      The Journal of biological chemistry  276  20673-8  2001

      Show Abstract
      11274171 11274171
      Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta.
      B Huppertz, H G Frank, J C Kingdom, F Reister, P Kaufmann, B Huppertz, H G Frank, J C Kingdom, F Reister, P Kaufmann
      Histochemistry and cell biology  110  495-508  1998

      Show Abstract
      9826129 9826129
      Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells
      Nagy, L., et al
      Leuk Res, 20:499-505 (1996)  1996

      Immunocytochemistry8709622 8709622

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