05-829X-555 | Anti-α-Tubulin Antibody, Alexa Fluor® 555 conjugate

05-829X-555
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Av, B, Gp, H, M, Po, RIFMAlexaFluor®555Monoclonal Antibody
      Description
      Catalogue Number05-829X-555
      Brand Family Chemicon®
      Trade Name
      • Upstate
      DescriptionAnti-α-Tubulin Antibody, Alexa Fluor® 555 conjugate
      References
      Product Information
      FormatAlexaFluor®555
      PresentationProtein G purified immunoglobulin conjugated to Alexa Fluor® 555. Liquid in PBS containing 1% BSA, 0.05% Tween®-20 and 0.05% sodium azide.
      Applications
      ApplicationAnti-α-Tubulin Antibody, Alexa Fluor 555 conjugate detects level of α-Tubulin & has been published & validated for use in IF.
      Key Applications
      • Immunofluorescence
      Biological Information
      ImmunogenThe epitope recognized by this antibody has been mapped to amino acids 426-450 (AALEKDYEEVGVDSV-EGEGEEEGEE).
      CloneDM1A
      HostMouse
      SpecificityRecognizes α-Tubulin
      IsotypeIgG1
      Species Reactivity
      • Avian
      • Bovine
      • Guinea Pig
      • Human
      • Mouse
      • Pig
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMicrotubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.
      Gene Symbol
      • TUBA1A
      • hum-a-tub2
      • FLJ25113
      • B-ALPHA-1
      • TUBA3
      • hum-a-tub1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q71U36 # Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
      SIZE: 451 amino acids; 50136 Da
      SUBUNIT: Dimer of alpha and beta chains.
      PTM: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity).
      SIMILARITY: SwissProt: Q71U36 ## Belongs to the tubulin family.
      Molecular Weight50-60 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunofluorescence
      Usage Statement
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 4°C for up to one year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti--Tubulin, clone DM1A, Alexa Fluor#174; 555 conjugate - 2073099 2073099
      Anti--Tubulin, clone DM1A, Alexa Fluor#174; 555 conjugate - DAM1739109 DAM1739109
      Anti--Tubulin, clone DM1A, Alexa Fluor#174; 555 conjugate - DAM1780345 DAM1780345
      Anti--Tubulin, clone DM1A, Alexa Fluor#174; 555 conjugate - DAM1817615 DAM1817615
      Anti--Tubulin, clone DM1A, Alexa Fluor#174; 555 conjugate - JBC1885045 JBC1885045
      Anti--Tubulin, clone DM1A, Alexa Fluor#174; 555 conjugate - JBC1913133 JBC1913133
      Anti--Tubulin, clone DM1A, Alexa Fluor#174; 555 conjugate - JBC1946360 JBC1946360
      Anti-alpha;-Tubulin, Alexa Fluor<SUP>reg;</SUP> 555 conjugate - D6D058 D6D058
      Anti-α-Tubulin, clone DM1A, Alexa Fluor® 555 conjugate (mouse monoclonal IgG1) - 2424759 2424759
      Anti-α-Tubulin, clone DM1A, Alexa Fluor® 555 conjugate (mouse monoclonal IgG1) 2939498

      References

      Reference overviewPub Med ID
      New microtubule/tubulin-targeted anticancer drugs and novel chemotherapeutic strategies.
      Wilson, L and Jordan, M A
      J Chemother, 16 Suppl 4: 83-5 (2004)  2004

      Show Abstract
      15688618 15688618
      Crystallographic structure of tubulin: implications for dynamics and drug binding.
      Downing, K H and Nogales, E
      Cell Struct. Funct., 24: 269-75 (1999)  1999

      Show Abstract
      15216882 15216882

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      Alternative Format

      Catalogue Number Description  
      05-829 Anti-α-Tubulin Antibody, clone DM1A Show Pricing & Availability
      16-232 Anti-α-Tubulin Antibody, clone DM1A, Alexa Fluor® 488 conjugate Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies