06-638 | Anti-Tyk2 Antibody

06-638
200 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-638
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Tyk2 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH7.4, 0.15M NaCl and 0.05% sodium azide
      Applications
      ApplicationAnti-Tyk2 Antibody detects level of Tyk2 & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion protein containing amino acids 249-396 of human Tyk2
      HostRabbit
      SpecificityTyk2
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TYK2
      • JTK1
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29597 # Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
      SIZE: 1187 amino acids; 133650 Da
      TISSUE SPECIFICITY: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
      SIMILARITY: SwissProt: P29597 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain.
      Molecular Weight130kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from TF1 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Tyk2 (rabbit polyclonal IgG) - 2410237 2410237
      Anti-Tyk2 (rabbit polyclonal IgG) 2903924
      Anti-Tyk2 (rabbit polyclonal IgG) - 1959261 1959261
      Anti-Tyk2 (rabbit polyclonal IgG) - 2032295 2032295
      Anti-Tyk2 (rabbit polyclonal IgG) - JBC1946378 JBC1946378
      Anti-Tyk2 (rabbit polyclonal IgG) -2506421 2506421
      Anti-Tyk2 - 16176 16176
      Anti-Tyk2 - 2054518 2054518
      Anti-Tyk2 - 21400 21400
      Anti-Tyk2 - 31390 31390

      References

      Reference overviewApplicationPub Med ID
      Inhibition of Jak1-dependent signal transduction in airway epithelial cells infected with adenovirus.
      Lei Shi, Murali Ramaswamy, Lori J Manzel, Dwight C Look, Lei Shi, Murali Ramaswamy, Lori J Manzel, Dwight C Look, Lei Shi, Murali Ramaswamy, Lori J Manzel, Dwight C Look
      American journal of respiratory cell and molecular biology  37  720-8  2007

      Show Abstract Full Text Article
      17641294 17641294
      Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction.
      Ramaswamy, M; Shi, L; Varga, SM; Barik, S; Behlke, MA; Look, DC
      Virology  344  328-39  2006

      Show Abstract
      16216295 16216295
      Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system.
      Vignais, M L and Gilman, M
      Mol. Cell. Biol., 19: 3727-35 (1999)  1999

      Show Abstract
      Immunoprecipitation10207096 10207096
      Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock
      Gatsios, P., et al
      J Biol Chem, 273:22962-8 (1998)  1998

      Immunoblotting (Western), Immunoprecipitation9722518 9722518
      Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1.
      Gollob, J A, et al.
      Blood, 91: 1341-54 (1998)  1998

      Show Abstract
      9454765 9454765
      Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.
      Schindler, C and Darnell, J E
      Annu. Rev. Biochem., 64: 621-51 (1995)  1995

      Show Abstract
      7574495 7574495