07-483 | Anti-UBB+1 Antibody, Ubi2a

100 µL  
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      Replacement Information
      Replacement Information04-454 is the recommended replacement for Discontinued catalog number 07-483

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbPurifiedPolyclonal Antibody
      Catalogue Number07-483
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-UBB+1 Antibody, Ubi2a
      Product Information
      Presentation0.05% sodium azide and 30% glycerol
      ApplicationThis Anti-UBB+1 Antibody, Ubi2a is validated for use in WB, IH for the detection of UBB+1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenThyroglobulin-conjugated, synthetic peptide corresponding to amino acids 85-95 of human UBB+1
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene SummaryThis gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
      Gene Symbol
      • RPS27A
      • CEP80
      • ubiquitin
      • ubiquitin-CEP80
      • UBCEP1
      • Ubiquitin.
      • UBA52
      • UBCEP2
      • UBA80
      • UBC
      • UBB
      • HUBCEP80
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
      SIZE: 76 amino acids; 8565 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
      SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
      MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).
      Molecular Weight11 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in bacterial lysates containing Histagged UBB+1
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information


      Certificates of Analysis

      TitleLot Number
      Anti-UBB<sup>+1</sup>, Ubi2a - 24555 24555


      Reference overviewApplicationPub Med ID
      Neuropeptide research discloses part of the secrets of Alzheimer's disease neuropathogenesis: state of the art 2004
      van Leeuwen, F. W.
      Neurosci Lett, 361:124-7 (2004)  2004

      15135909 15135909
      Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases
      De Pril, R., et al
      Hum Mol Genet, 13:1803-13 (2004)  2004

      Immunohistochemistry (Tissue)15198995 15198995
      Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers
      Fratta, P., et al
      Neurology, 63:1114-7 (2004)  2004

      Immunohistochemistry (Tissue)15452314 15452314
      Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression
      Hope, A. D., et al
      J Neurochem, 86:394-404 (2003)  2003

      Immunocytochemistry12871580 12871580
      Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity
      Song, S., et al
      Mol Cell, 12:553-63 (2003)  2003

      14527403 14527403
      The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
      Ciechanover, A. and Brundin, P.
      Neuron, 40:427-46 (2003)  2003

      14556719 14556719
      Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain.
      Fischer, DF; De Vos, RA; Van Dijk, R; De Vrij, FM; Proper, EA; Sonnemans, MA; Verhage, MC; Sluijs, JA; Hobo, B; Zouambia, M; Steur, EN; Kamphorst, W; Hol, EM; Van Leeuwen, FW
      FASEB journal : official publication of the Federation of American Societies for Experimental Biology  17  2014-24  2003

      Show Abstract
      Immunohistochemistry14597671 14597671
      Molecular misreading of the ubiquitin B gene and hepatic mallory body formation
      McPhaul, L. W., et al
      Gastroenterology, 122:1878-85 (2002)  2002

      Immunohistochemistry (Tissue), Immunoblotting (Western)12055595 12055595
      Molecular misreading: a new type of transcript mutation expressed during aging
      van Leeuwen, F. W., et al
      Neurobiol Aging, 21:879-91 (2000)  2000

      11124436 11124436
      Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients.
      van Leeuwen, F W, et al.
      Science, 279: 242-7 (1998)  1998

      Show Abstract
      9422699 9422699

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      Life Science Research > Antibodies and Assays > Primary Antibodies