05-1947 | Anti-USP7 Antibody, clone 7G9

05-1947
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1947
      DescriptionAnti-USP7 Antibody, clone 7G9
      Alternate Names
      • ubiquitin specific peptidase 7 (herpes virus-associated)
      • Ubiquitin-specific-processing protease 7
      • ubiquitin specific protease 7 (herpes virus-associated)
      • Herpesvirus-associated ubiquitin-specific protease
      • Herpes virus-associated ubiquitin-specific protease
      • Ubiquitin thioesterase 7
      • ubiquitin specific peptidase 7
      • Deubiquitinating enzyme 7
      • HAUSP
      Background InformationUbiquitin carboxyl-terminal hydrolase 7(USP7) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates.[Saridakis, 2005] Since ubiquitylation (polyubiquitination) is most commonly associated with the stability and degradation of cellular proteins, Ubiquitin carboxyl-terminal hydrolase 7 activity generally stabilizes its substrate proteins. Ubiquitin carboxyl-terminal hydrolase 7 is most popularly known as a direct antagonist of Mdm2, the E3 ubiquitin ligase for the tumor suppressor protein, p53.[Canning, 2004]
      References
      Product Information
      FormatPurified
      Control
      • HeLa cell lysates
      PresentationPurified IgG2bκ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationDetect USP7 using this Anti-USP7 Antibody, clone 7G9 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHis-tagged recombinant human protein corresponding to the C-terminus of USP7.
      EpitopeC-terminus
      Clone7G9
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityAntibody recognizes the C-terminus of USP7.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • USP7
      • TEF1
      • HAUSP
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryCleaves ubiquitin fusion protein substrates. Deubiquitinates TP53/p53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis.
      Molecular Weight128 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysates.

      Western Blotting Analysis: 0.25 µg/mL of this antibody detected USP7 in HeLa cell lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies