05-944 | Anti-Ubiquitin Antibody, clone P4D1-A11

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Vrt, Yeast (S. cerevisiae)WBMPurifiedMonoclonal Antibody
      Catalogue Number05-944
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Ubiquitin Antibody, clone P4D1-A11
      Product Information
      Presentation100 μg of protein G purified mouse IgG in 100 μL of 70% storage buffer (0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide) and 30% glycerol.
      ApplicationAnti-Ubiquitin Antibody, clone P4D1-A11 is an antibody against Ubiquitin for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogentotal bovine ubiquitin
      SpecificityUbiquitin, Mr = 8 kDa, and several ubiquitinated proteins
      Species Reactivity
      • Human
      • Vertebrates
      • Yeast (S. cerevisiae)
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
      Gene Symbol
      • RPS27A
      • CEP80
      • ubiquitin
      • ubiquitin-CEP80
      • UBCEP1
      • Ubiquitin.
      • UBA52
      • UBCEP2
      • UBA80
      • UBC
      • UBB
      • HUBCEP80
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P62988 # Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous fonctions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.
      SIZE: 76 amino acids; 8565 Da
      SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
      PTM: Several types of polymeric chains can be formed, depending on the lysine used for the assembly.
      SIMILARITY: SwissProt: P62988 ## Belongs to the ubiquitin family.
      MISCELLANEOUS: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).
      Molecular Weight8 kDa and higher
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot of human recombinant ubiquitin (Catalog # 12-558), and ubiquitinated proteins in acid extracts from HeLa cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Ubiquitin, clone P4D1-A11 (mouse monoclonal IgG) - 2080302 2080302
      Anti-Ubiquitin, clone P4D1-A11 (mouse monoclonal IgG) - 2370144 2370144
      Anti-Ubiquitin, clone P4D1-A11 (mouse monoclonal IgG) - 2327458 2327458
      Anti-Ubiquitin, clone P4D1-A11 (mouse monoclonal IgG) 2895882
      Anti-Ubiquitin, clone P4D1-A11 (mouse monoclonal IgG) - 2210391 2210391
      Anti-Ubiquitin, clone P4D1-A11 (mouse monoclonal IgG) - JBC1936156 JBC1936156
      Anti-Ubiquitin, clone P4D1-A11 - 0702051809 0702051809
      Anti-Ubiquitin, clone P4D1-A11 - 30543 30543
      Anti-Ubiquitin, clone P4D1-A11 - DAM1418753 DAM1418753
      Anti-Ubiquitin, clone P4D1-A11 - DAM1612161 DAM1612161


      Reference overviewApplicationPub Med ID
      In vivo monoubiquitination of anaplerotic phosphoenolpyruvate carboxylase occurs at Lys624 in germinating sorghum seeds.
      Ruiz-Ballesta, I; Feria, AB; Ni, H; She, YM; Plaxton, WC; Echevarría, C
      Journal of experimental botany  65  443-51  2014

      Show Abstract
      24288181 24288181
      The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.
      Sparks, A; Dayal, S; Das, J; Robertson, P; Menendez, S; Saville, MK
      Oncogene  33  4685-96  2014

      Show Abstract
      Western Blotting24121268 24121268
      Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3.
      Getty, A; Kovács, AD; Lengyel-Nelson, T; Cardillo, A; Hof, C; Chan, CH; Pearce, DA
      PloS one  8  e66203  2013

      Show Abstract
      23840424 23840424
      Tissue-specific expression and post-translational modifications of plant- and bacterial-type phosphoenolpyruvate carboxylase isozymes of the castor oil plant, Ricinus communis L.
      O'Leary, B; Fedosejevs, ET; Hill, AT; Bettridge, J; Park, J; Rao, SK; Leach, CA; Plaxton, WC
      Journal of experimental botany  62  5485-95  2011

      Show Abstract
      21841182 21841182
      The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.
      Solinger, JA; Paolinelli, R; Klöss, H; Scorza, FB; Marchesi, S; Sauder, U; Mitsushima, D; Capuani, F; Stürzenbaum, SR; Cassata, G
      PLoS genetics  6  e1000820  2010

      Show Abstract
      20107598 20107598
      Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.
      Shona Mookerjee,Theodora Papanikolaou,Stephan J Guyenet,Vanitha Sampath,Amy Lin,Cathy Vitelli,Francesco DeGiacomo,Bryce L Sopher,Sylvia F Chen,Albert R La Spada,Lisa M Ellerby
      The Journal of neuroscience : the official journal of the Society for Neuroscience  29  2009

      Show Abstract Full Text Article
      19955365 19955365
      Regulatory monoubiquitination of phosphoenolpyruvate carboxylase in germinating castor oil seeds.
      Uhrig, RG; She, YM; Leach, CA; Plaxton, WC
      The Journal of biological chemistry  283  29650-7  2008

      Show Abstract
      Western Blotting18728004 18728004
      The ubiquitin-proteasome pathway and its role in cancer.
      Mani, Aparna and Gelmann, Edward P
      J. Clin. Oncol., 23: 4776-89 (2005)  2005

      Show Abstract
      16034054 16034054
      The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle.
      Hershko, A
      Cell Death Differ., 12: 1191-7 (2005)  2005

      Show Abstract
      16094395 16094395
      Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli.
      Gao, Min and Karin, Michael
      Mol. Cell, 19: 581-93 (2005)  2005

      Show Abstract
      16137616 16137616

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      Life Science Research > Antibodies and Assays > Primary Antibodies