06-1038 | Anti-Unc84B/SUN2 Antibody

06-1038
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, Ca, EqIP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1038
      DescriptionAnti-Unc84B/SUN2 Antibody
      Alternate Names
      • Rab5-interacting protein
      • Sad1 unc-84 domain protein 2
      • Sad1/unc-84 protein-like 2
      • nuclear envelope protein
      • unc-84 homolog B
      • unc-84 homolog B (C. elegans)
      Background InformationUNC84B (Protein UNC-84 homolog B or SUN2), is a single-pass nuclear envelope transmembrane protein responsible for nuclear migrations that are essential for development. UNC-84B has a predicted transmembrane domain and a C-terminal region with similarity to the S. pombe spindle pole body protein Sad1. UNC-84B interacts with RAB5A and is widely expressed, and highly expressed in the heart, lungs and muscles. UNC-84 may function to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage.
      References
      Product Information
      FormatAffinity Purified
      Control
      • U2OS cell lysate.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-Unc84B/SUN2 Antibody is validated for use in Immunoprecipitation and Western Blotting for the detection of Unc84B/SUN2.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated Unc84B/SUN2 from 500 µg of U2OS cell lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Unc84B/SUN2 at and around the N-terminus.
      EpitopeN-terminus
      Concentration0.5 mg/mL
      HostRabbit
      SpecificityThis antibody recognizes Unc84B/SUN2 at the N-terminus.
      IsotypeIgG
      Species Reactivity
      • Human
      • Canine
      • Horse
      Species Reactivity NoteProven to react with human. Predicted to react with dog and horse based on sequence homology. Mouse and rat (87%).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FRIGG
      • UNC84B
      • RAB5IP
      • Rab5IP
      • SUN2
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummarySUBUNIT STRUCTURE: Interacts with RAB5A.

      SUBCELLULAR LOCATION: Nucleus membrane; Single-pass membrane protein. Endosome membrane; Single-pass membrane protein Probable.

      TISSUE SPECIFICTY: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.

      DOMAIN: The Unc84 domain may play a role in the nuclear anchoring and/or migration.

      SEQUENCE SIMILARITIES: Contains 1 Unc84 (SUN) domain.

      Caution It is uncertain whether Met-1 or Met-50 is the initiator.
      Molecular Weight~80 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in U2OS cell lysate.

      Western Blot (SNAP ID) Analysis: 1:250 dilution of this antibody detected Unc84B/SUN2 on 10 µg of U2OS cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Unc84B/SUN2 - 1979263 1979263
      Anti-Unc84B/SUN2 - NRG1653647 NRG1653647
      Anti-Unc84B/Sun2 -2800520 2800520
      Anti-Unc84B/Sun2 -2858877 2858877
      Anti-Unc84B/Sun2 Polyclonal Antibody 2918917

      References

      Reference overviewApplicationPub Med ID
      Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.
      Zuleger, N; Boyle, S; Kelly, DA; de las Heras, JI; Lazou, V; Korfali, N; Batrakou, DG; Randles, KN; Morris, GE; Harrison, DJ; Bickmore, WA; Schirmer, EC
      Genome biology  14  R14  2013

      Show Abstract
      23414781 23414781
      Several novel nuclear envelope transmembrane proteins identified in skeletal muscle have cytoskeletal associations.
      Wilkie, GS; Korfali, N; Swanson, SK; Malik, P; Srsen, V; Batrakou, DG; de las Heras, J; Zuleger, N; Kerr, AR; Florens, L; Schirmer, EC
      Molecular & cellular proteomics : MCP  10  M110.003129  2011

      Show Abstract Full Text Article
      Western Blotting20876400 20876400
      The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture.
      Korfali, N; Wilkie, GS; Swanson, SK; Srsen, V; Batrakou, DG; Fairley, EA; Malik, P; Zuleger, N; Goncharevich, A; de Las Heras, J; Kelly, DA; Kerr, AR; Florens, L; Schirmer, EC
      Molecular & cellular proteomics : MCP  9  2571-85  2010

      Show Abstract
      Western Blotting20693407 20693407

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies