05-219 | Anti-Vav Antibody

05-219
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMAscitesMonoclonal Antibody
      Description
      Catalogue Number05-219
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Vav Antibody
      References
      Product Information
      FormatAscites
      Presentationascites fluid containing 0.05% sodium azide
      Applications
      ApplicationAnti-Vav Antibody is an antibody against Vav for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-fusion to full length human Vav
      HostMouse
      Specificityhuman and murine p95vav and p85vav
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
      Gene Symbol
      • VAV1
      • VAV
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P15498 # Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
      SIZE: 845 amino acids; 98314 Da
      SUBUNIT: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB.
      TISSUE SPECIFICITY: Widely expressed in hematopoietic cells but not in other cell types.
      DOMAIN: SwissProt: P15498 The DH domain is involved in interaction with CCPG1 (By similarity).
      PTM: Phosphorylated on tyrosine residues.
      SIMILARITY: Contains 1 CH (calponin-homology) domain. & Contains 1 DH (DBL-homology) domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 SH2 domain. & Contains 2 SH3 domains.
      MISCELLANEOUS: 'Vav' stands for the sixth letter of the Hebrew alphabet.
      Molecular Weight95 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated on RIPA lysates of Jurkat cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Vav (mouse ascites) - 2450100 2450100
      Anti-Vav (mouse ascites) - 1958323 1958323
      Anti-Vav (mouse ascites) - JBC1900829 JBC1900829
      Anti-Vav - 16306 16306
      Anti-Vav - 17851 17851
      Anti-Vav - 18583 18583
      Anti-Vav - 19224 19224
      Anti-Vav - 2044813 2044813
      Anti-Vav - 22585 22585
      Anti-Vav - 2510220 2510220

      References

      Reference overviewApplicationPub Med ID
      CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
      Chiang, YJ; Ho, KC; Sun, CT; Chiu, JJ; Lee, FJ; Liao, F; Yang-Yen, HF; Yen, JJ
      PloS one  8  e61761  2013

      Show Abstract
      Fluorescence Activated Cell Sorting (FACS)23620790 23620790
      Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.
      Jha, MK; Badou, A; Meissner, M; McRory, JE; Freichel, M; Flockerzi, V; Flavell, RA
      Nature immunology  10  1275-82  2009

      Show Abstract
      19838200 19838200
      The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.
      Ming, W; Li, S; Billadeau, DD; Quilliam, LA; Dinauer, MC
      Molecular and cellular biology  27  312-23  2007

      Show Abstract Full Text Article
      17060455 17060455
      An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
      Jo, E. K., et al
      J Exp Med, 201:1733-9 (2005)  2005

      Immunoblotting (Western)15939789 15939789
      hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.
      Germani, A, et al.
      Mol. Cell. Biol., 19: 3798-807 (1999)  1999

      Show Abstract
      Immunoblotting (Western)10207103 10207103
      Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment.
      Ogilvy, S, et al.
      Blood, 91: 419-30 (1998)  1998

      Show Abstract
      Immunoblotting (Western)9427694 9427694
      Interleukin 5 signals through Shc and Grb2 in human eosinophils
      Bates, M. E., et al
      Am J Respir Cell Mol Biol, 18:75-83 (1998)  1998

      Immunoblotting (Western)9448048 9448048
      LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
      Zhang, W, et al.
      Cell, 92: 83-92 (1998)  1998

      Show Abstract
      Immunoblotting (Western)9489702 9489702
      Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity
      Shigematsu, H., et al
      J Biol Chem, 272:14334-40 (1997)  1997

      Immunoblotting (Western)9162069 9162069
      The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.
      Kon-Kozlowski, M, et al.
      J. Biol. Chem., 271: 3856-62 (1996)  1996

      Show Abstract
      Immunoprecipitation8632004 8632004

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies