05-1569 | Anti-Vav2 Antibody, clone MAC 411

05-1569
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1569
      DescriptionAnti-Vav2 Antibody, clone MAC 411
      Alternate Names
      • vav 2 guanine nucleotide exchange factor
      • vav 2 oncogene
      • Protein vav-2
      • oncogene VAV2
      • guanine nucleotide exchange factor VAV2
      Background InformationGuanine nucleotide exchange factor Vav2 (VAV-2) is a novel protein shown to have specific activity toward the Rho family of RAS-like GTPases. This protein is expressed in most tissues, in contrast to VAV1 which is expressed mainly in hematipoietic cells. Vav2 is comprised of several domains including: a CH domain, a DH domain, a PH domain, and SH2 domain, two SH3 domains, and a phorbol-ester/DAG-type zinc finger domain. Studies have demonstrated Vav2 to be a critical component in angiogenesis, and that its activation via RPHA2 phosphorylation is necessary to the activation of EFNA1-induced RAC1 GTPase. Its activation is also important in the migration and assembly of vascular endothelial cells.
      References
      Product Information
      FormatPurified
      Control
      • C2C12 cell lysate
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationDetect Vav2 using this Anti-Vav2 Antibody, clone MAC 411 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse Vav2.
      CloneMAC411
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VAV-2
      • VAV2
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.

      SUBUNIT STRUCTURE: Interacts (via SH2 domains) with the phosphorylated form of EPHA2.

      SEQUENCE SIMILARITIES: Contains 1 CH (calponin-homology) domain.

      Contains 1 DH (DBL-homology) domain.

      Contains 1 PH domain.

      Contains 1 phorbol-ester/DAG-type zinc finger.

      Contains 1 SH2 domain.

      Contains 2 SH3 domains.
      Molecular Weight~ 100 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in C2C12 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Vav2 on 10 µg of C2C12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      Anti-Vav2, clone MAC 411 - NRG1817781 NRG1817781

      References

      Reference overviewPub Med ID
      Mesoscopic gel at low agarose concentration in water: a dynamic light scattering study.
      D Bulone,P L San Biagio
      Biophysical journal  68  1995

      Show Abstract Full Text Article
      7787042 7787042