07-037 | Anti-WAVE/Scar Antibody

07-037
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-037
      ReplacesAB3821
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-WAVE/Scar Antibody
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
      Applications
      ApplicationAnti-WAVE/Scar Antibody is an antibody against WAVE/Scar for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion-protein corresponding to full length (residues 1-559) of human WAVE/Scar
      HostRabbit
      SpecificityWAVE/Scar
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • WASF1
      • KIAA0269
      • FLJ31482
      • SCAR1
      • WAVE1
      • WAVE
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q92558 # Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.
      SIZE: 559 amino acids; 61652 Da
      SUBUNIT: Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2.
      SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane- ruffling areas.
      TISSUE SPECIFICITY: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
      DOMAIN:SwissProt: Q92558 Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
      SIMILARITY: Contains 1 WH2 domain.
      Molecular Weight84kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from mouse 3T3/A31 fibroblasts
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-WAVE/Scar (rabbit polyclonal IgG) 2975283
      Anti-WAVE/Scar - 19562 19562
      Anti-WAVE/Scar - 26517 26517
      Anti-WAVE/Scar -2798350 2798350
      Anti-WAVE/Scar -2823940 2823940
      AntiAnti -WAVE/Scar -2819401 2819401

      References

      Reference overviewApplicationPub Med ID
      Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel.
      Karpushev, AV; Levchenko, V; Ilatovskaya, DV; Pavlov, TS; Staruschenko, A
      Hypertension  57  996-1002  2011

      Show Abstract
      Immunohistochemistry21464391 21464391
      Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.
      Suetsugu, S, et al.
      Biochem. Biophys. Res. Commun., 260: 296-302 (1999)  1999

      Show Abstract
      10381382 10381382

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies