06-1358 | Anti-acetyl (Lys34) phospho (Ser36) Histone H1 Antibody

06-1358
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, HWB, DBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-1358
      DescriptionAnti-acetyl (Lys34) phospho (Ser36) Histone H1 Antibody
      Alternate Names
      • Histone H1.4
      • Histone H1b
      Background InformationH1.4 is one of four variants of histone H1 (H1.2-H1.5) that is found in somatic cells. The H1 histones may function as linker proteins binding DNA via their GH domain, and enabling the wrapping of DNA around the core nucleosomal structure formed from the association of H2A, H2B, H3, and H4. In response to various stimuli, histones undergo a number of post-translational modifications (PTM) including acetylation, phoshorylation, and methylation. Previous studies have suggested that H1.4 may be phosphorylated during mitosis and interphase resulting in increased transcription of target genes by RNA polymerase I and II, and therefore this PTM on H1.4 may have implications for cell growth. H1.4 may also undergo acetylation of its N-terminal lysine residues. Often, it is the pattern of different modifications on several histone residues that alter chromatin and affect gene expression, rather than modification of single residues.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Calf thymus histone extract
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationUse Anti-acetyl (Lys34) phospho (Ser36) Histone H1 Antibody (Rabbit Polyclonal Antibody) validated in WB & DB to detect acetyl (Lys34) phospho (Ser36) Histone H1 also known as Histone H1b.
      Key Applications
      • Western Blotting
      • Dot Blot
      Application NotesDot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with acetyl (Lys34) phospho (Ser36) Histone H1.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Histone H1 acetylated at Lys34 and phosphorylated at Ser36.
      EpitopeAcetylated Lys34 and phosphorylated Ser36
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Histone H1 acetylated at Lys34 and phosphorylated at Ser36.
      Species Reactivity
      • Bovine
      • Human
      Species Reactivity NoteDemonstrated to react with Bovine and Human. Predicted to react with Canine and Rhesus macaque based on 100% sequence homology. Other homologies: Mouse and Rat (90% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST1H1E
      • H1F4
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~34 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in calf thymus histone extract.

      Western Blot Analysis: A 1:37 dilution of this antibody detected Histone H1 on 10 µg of calf thymus histone extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies