09-040 | Anti-c-Rel (NFκB) Antibody

09-040
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, EMSA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number09-040
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-c-Rel (NFκB) Antibody
      Alternate Names
      • REL
      References
      Product Information
      FormatAffinity Purified
      Presentation100 μg of immunoaffinity purified rabbit polyclonal IgG in 0.02M PBS, 0.25M sodium chloride (pH 7.6) containing 0.1% sodium azide.
      Applications
      ApplicationDetect c-Rel (NFκB) using this Anti-c-Rel (NFκB) Antibody validated for use in ELISA, EMSA & WB.
      Key Applications
      • ELISA
      • Electrophoretic Mobility Shift Assay
      • Western Blotting
      Application NotesImmunoblot Analysis: A 0.5 g/mL dilution of this lot detected c-Rel in Raji cell lysate.

      EMSA: This antibody has been shown to perform in DNA binding experiments.

      ELISA: A 1:1,000 dilution of this antibody detected endogenous c-Rel in Raji cell lysate in non-denaturing conditions.
      Biological Information
      ImmunogenKLH conjugated synthetic peptide (C- MMTTSSDSMGETDNPRLLSM) corresponding to amino acids 498-517 of human c-Rel
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes c-Rel
      IsotypeIgG
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • REL
      • I-Rel
      • C-Rel
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q04864 # Proto-oncogene that may play a role in differentiation and lymphopoiesis. May function as a transcriptional transactivator.
      SIZE: 619 amino acids; 68520 Da
      SUBUNIT: Homodimer (By similarity). Interacts with NKIRAS1.
      SUBCELLULAR LOCATION: Nucleus (By similarity).
      SIMILARITY: SwissProt: Q04864 ## Contains 1 RHD (Rel-like) domain.
      Molecular Weight70 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-c-Rel (NF#954;B) (Rabbit Immunoaffinity purified IgG) - DAM1821162 DAM1821162
      Anti-c-Rel (NFkB) (Rabbit Immunoaffinity purified IgG) 2930109
      Anti-c-Rel (NFkB) - 2073694 2073694
      Anti-c-Rel (NFkB) - DAM1683933 DAM1683933
      Anti-c-Rel (NFkB) - DAM1718093 DAM1718093
      Anti-c-Rel (NFkB) - DAM1780410 DAM1780410
      Anti-c-Rel (NFkB) - DAM1810839 DAM1810839
      Anti-c-Rel (NFκB) (Rabbit Immunoaffinity purified IgG) - 2526832 2526832
      anti-c-Rel (NFkappa;B) - 0611044486 0611044486
      anti-c-Rel (NFkappa;B) - DAM1394845 DAM1394845

      References

      Reference overviewPub Med ID
      The structure of the TNFRSF13C promoter enables differential expression of BAFF-R during B cell ontogeny and terminal differentiation.
      Mihalcik, SA; Huddleston, PM; Wu, X; Jelinek, DF
      Journal of immunology (Baltimore, Md. : 1950)  185  1045-54  2010

      Show Abstract
      20554963 20554963
      Divergent C-terminal transactivation domains of Rel/NF-kappa B proteins are critical determinants of their oncogenic potential in lymphocytes
      Fan, Yongjun, et al
      Oncogene, 23:1030-42 (2004)  2004

      14647412 14647412
      Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling
      Chen, Xufeng, et al
      Cancer Res, 63:1059-66 (2003)  2003

      12615723 12615723

      Brochure

      Title
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling