CBL430 | Anti-c-myc Antibody, clone 9E10

CBL430
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL430
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-c-myc Antibody, clone 9E10
      References
      Product Information
      FormatPurified
      PresentationThe monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Applications
      ApplicationAnti-c-myc Antibody, clone 9E10 is a Mouse Monoclonal Antibody for detection of c-myc also known as Proto-oncogene c-Myc & has been tested in WB, IHC(P).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesEpitope tagging on sequence EQKLISEEDL

      Western blotting of myc-tagged recombinant proteins and re combinant myc

      Immunohistochemical staining of formalin and fixed paraffin embedded tissue sections and also acetone fixed frozen sections

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to the carboxy terminal of human c-myc
      Epitopea.a. 408-438
      Clone9E10
      HostMouse
      SpecificityKNOWN SPECIES CROSS REACTIVITY: Weakly cross-reactive with mouse but not rat
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
      Gene Symbol
      • MYC
      • C-MYC
      • c-Myc
      Non-Reactive Species
      • Rat
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.
      SIZE: 439 amino acids; 48804 Da
      SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.
      SUBCELLULAR LOCATION: Nucleus.
      PTM: Phosphorylated by PRKDC.
      DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
      SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overviewPub Med ID
      Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters.
      A M Kocabas, G Rudnick, F Kilic
      Journal of neurochemistry  85  1513-20  2003

      Show Abstract
      12787070 12787070
      Primary structure and function of a second essential member of the heterooligomeric TCP1 chaperonin complex of yeast, TCP1 beta.
      Miklos, D, et al.
      Proc. Natl. Acad. Sci. U.S.A., 91: 2743-7 (1994)  1994

      Show Abstract
      7908441 7908441
      Cellular localisation of c-myc product in human colorectal epithelial neoplasia.
      Royds, J A, et al.
      J. Pathol., 166: 225-33 (1992)  1992

      Show Abstract
      1381423 1381423
      The alternative carboxyl termini of avian cardiac and brain sarcoplasmic reticulum/endoplasmic reticulum Ca(2+)-ATPases are on opposite sides of the membrane.
      Campbell, A M, et al.
      J. Biol. Chem., 267: 9321-5 (1992)  1992

      Show Abstract
      1533629 1533629
      Implication of the ras and myc oncoproteins in the pathogenesis of mycosis fungoides.
      Tosca, A, et al.
      Anticancer Res., 11: 1433-8 (1991)  1991

      Show Abstract
      1746900 1746900
      c-myc oncoprotein in bronchial carcinoma: expression in all major morphological types.
      Gosney, J R, et al.
      Anticancer Res., 10: 623-8 (1990)  1990

      Show Abstract
      2164348 2164348
      Evaluation of the ras and myc oncoproteins in benign gastric lesions.
      Karayiannis, M, et al.
      Anticancer Res., 10: 1127-33 (1990)  1990

      Show Abstract
      2241094 2241094
      Expression of ras and myc oncogenes in human hepatocellular carcinoma and non-neoplastic liver tissues.
      Tiniakos, D, et al.
      Anticancer Res., 9: 715-21 (1989)  1989

      Show Abstract
      2548435 2548435
      ras, c-myc and c-erbB-2 oncoproteins in human breast cancer.
      Spandidos, D A, et al.
      Anticancer Res., 9: 1385-93 (1989)  1989

      Show Abstract
      2574023 2574023
      Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
      Evan, G I, et al.
      Mol. Cell. Biol., 5: 3610-6 (1985)  1985

      Show Abstract
      3915782 3915782

      Data Sheet

      Title
      Anti-c-myc, a.a. 408-438, clone 9E10 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies