06-676 | Anti-mGluR2/3 Antibody

06-676
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RIHC, IP, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-676
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-mGluR2/3 Antibody
      References
      Product Information
      FormatPurified
      Presentation0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol
      Applications
      ApplicationAnti-mGluR2/3 Antibody is an antibody against mGluR2/3 for use in IH, IP & WB.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      Immunogenpeptide (KQFVPTVCNGREVVDSTTSSL) corresponding to amino acids 853-872 of human metabotropic glutamate receptor 2
      HostRabbit
      SpecificitymGluR2 and mGluR3
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
      Gene Symbol
      • GRM2
      • GPRC1B
      • MGLUR2
      • GLUR2
      • mGlu2
      • mGluR2
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
      SIZE: 872 amino acids; 95568 Da
      SUBUNIT: Interacts with GRASP (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain.
      SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family.
      Molecular Weight100-110kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on rat brain microsomal preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-mGluR2/3 2474896
      Anti-mGluR2/3 - 16955 16955
      Anti-mGluR2/3 - 28752 28752
      Anti-mGluR2/3 Polyclonal Antibody 2921508

      References

      Reference overviewPub Med ID
      Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.
      Dhanya, RP; Sheffler, DJ; Dahl, R; Davis, M; Lee, PS; Yang, L; Nickols, HH; Cho, HP; Smith, LH; D'Souza, MS; Conn, PJ; Der-Avakian, A; Markou, A; Cosford, ND
      Journal of medicinal chemistry  57  4154-72  2014

      Show Abstract
      24735492 24735492
      Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects.
      M Behnam Ghasemzadeh,Preethi Vasudevan,Christopher Mueller
      Pharmacology, biochemistry, and behavior  92  2009

      Show Abstract
      19135470 19135470
      Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.
      Shigemoto, R, et al.
      J. Neurosci., 17: 7503-22 (1997)  1997

      Show Abstract
      9295396 9295396
      The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations.
      Petralia, R S, et al.
      Neuroscience, 71: 949-76 (1996)  1996

      Show Abstract
      8684625 8684625
      Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus.
      Petralia, R S, et al.
      J. Comp. Neurol., 372: 356-83 (1996)  1996

      Show Abstract
      8873866 8873866
      Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3.
      Emile, L, et al.
      Neuropharmacology, 35: 523-30 (1996)  1996

      Show Abstract
      8887960 8887960
      Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus.
      Blümcke, I, et al.
      Brain Res., 736: 217-26 (1996)  1996

      8930327 8930327

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies