07-436-AF488 | Anti-monomethyl Histone H3 (Lys4) Antibody, Alexa Fluor® 488 Conjugate

07-436-AF488
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICCRbAlexaFluor®488Polyclonal Antibody
      Description
      Catalogue Number07-436-AF488
      DescriptionAnti-monomethyl Histone H3 (Lys4) Antibody, Alexa Fluor® 488 Conjugate
      Alternate Names
      • Histone H3.1t
      • H3/t
      • H3t
      • H3/g
      Background InformationHistone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Histone proteins are highly post-translationally modified, and Histone H3 is the most extensively modified of the five histones. Histone H3 sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes. Di- and tri-methylation of histone H3 are gene silencing marks, while removal of these marks by the demethylase genes Jmjd1a and Jmjd2c leads to gene activation. This product is a conjugated version of Cat. No. 07-436.
      References
      Product Information
      FormatAlexaFluor®488
      PresentationPurified rabbit Alexa Fluor® 488 conjugated antibody in buffer containing PBS with 15 mg/ml BSA and 0.1% Sodium Azide.
      Applications
      ApplicationThis Anti-monomethyl Histone H3 (Lys4) Antibody, Alexa Fluor® 488 Conjugate is validated for use in ICC for the detection of monomethyl Histone H3 (Lys4).
      Key Applications
      • Immunocytochemistry
      Biological Information
      ImmunogenLinear peptide corresponding to Histone H3 monomethylated at Lys4.
      Concentration0.5 mg/mL
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Vertebrates based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST3H3
      • H3FT
      Purification MethodProtein A Purfied
      UniProt Number
      Molecular Weight~17 kDa observed (Refer to Cat. No. 07-436)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunocytochemisty Analysis in HeLa cells.

      Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected monomethyl Histone H3 (Lys4) in HeLa cells.

      Alexa Fluor® is a registered trademark of Life Technologies®.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications