CBL1346Z-I | Anti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free)

CBL1346Z-I
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IP, FCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL1346Z-I
      ReplacesCBL1346Z
      DescriptionAnti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free)
      Alternate Names
      • Integrin alpha-V
      • Vitronectin receptor subunit alpha
      • CD51
      • 1.Integrin alpha-V heavy chain2.Integrin alpha-V light chain
      • Integrin alphaV
      Background InformationIntegrin alphaV, also known as CD51, a member of the integrin family, is a 140 kD protein expressed on activated T cells, polymorphonuclear granulocytes, blastocysts, and osteoclasts. Integrin alphaV forms heterodimers by association with integrins beta1, beta3, beta5 or beta6, these complexes then act as receptors for multiple extracellular matrix proteins (ECM). The alphaV integrins have varied functions in development, stimulation/activation and homeostasis. The primary ligands for Integrin alphaV complexes are fibronectin, fibrinogen, vitronectin, thrombspondin, von Willebrand factor, and CD31.
      References
      Product Information
      FormatPurified
      Control
      • Murine 3T3-L1 cells
      PresentationPurified rat monoclonal IgG1κ in buffer containing PBS without preservatives.
      Applications
      ApplicationThis Anti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free) is validated for use in Western Blotting, Immunoprecipitation, Flow Cytometry for the detection of mouse Integrin alphaV.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Flow Cytometry
      Application NotesWestern Blot Analysis: A representative lot was used by an independent laboratory in LAK cell lysate. (Takahashi, K. et al., (1990). J. Immunol. 145:4371.)

      Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in LAK cell lysate. (Takahashi, K. et al., (1990). J. Immunol. 145:4371.)

      Blocking Assay: Adhesion and LAK cell cytotoxicity was shown using a representative lot (Takahashi, K. et al., (1990). J. Immunol. 145:4371.)
      Biological Information
      ImmunogenBALB/c mouse IL-2–activated killer (LAK) cells
      CloneRMV-7
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificitySpecifically recognizes Integrin alphaV, also known as CD51 or vitronectin receptor. This antibody has been reported to block binding of Integrin alphaV to vitronectin, fibronectin, fibrinogen, and CD31 in some cell types, as well as, blocking LAK cell cytotoxicity.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Itgav
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~140 kDa observed. The calculated molecular weight is 115 kDa, however Integrin alphaV has been shown as a ~140 kDa band in western blots (Takahashi, K. et al., (1990). J. Immunol. 145:4371.).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in murine 3T3-L1 cells.

      Flow Cytometry Analysis: 0.2 µg of this antibody detected Integrin alphaV in murine 3T3-L1 cells .
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-mouse Integrin alphaV, clone -2718261 2718261
      Anti-mouse Integrin alphaV, clone RMV-7 2472968
      Anti-mouse Integrin alphaV, clone RMV-7 (Preservative free) - Q2067202 Q2067202

      References

      Reference overviewPub Med ID
      A murine very late activationantigen-like extracellular matrix receptor involved in CD2- and lymphocyte function-associated antigen-1-independent killer-targetcell interaction
      Takahashi, K. et al.
      J. Immunol., 145:4371­4379 (1990)  1990

      1979586 1979586

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies