09-260 | Anti-mouse Tks4 Antibody

100 µg   
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, ICC, IPRbPurifiedPolyclonal Antibody
      Catalogue Number09-260
      DescriptionAnti-mouse Tks4 Antibody
      Background InformationTks4 (gene symbol SH3PXD2B) is a novel adaptor protein; also known as SH3 and PX domain-containing protein 2B, (Courtneidge, 2005). It is closely related to Tks5 (gene symbol SH3PXD2A) and like Tks5, appears to play a role in the formation and function of podosome/invadopodia based on studies of Src-transformed fibroblasts (Buschman, 2009). Additionally, Tks4 may be involved in the recruitment of MT1-MMP and ECM degradation.
      Tks4 is broadly expressed and localizes in the cytoplasm of the podosome.
      Product Information
      • NIH3T3 cell lysate.
      PresentationPurified in 0.1M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% NaN3.
      ApplicationAnti-mouse Tks4 Antibody is an antibody against mouse Tks4 for use in WB, IC & IP.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunoprecipitation
      Biological Information
      ImmunogenRecombinant protein containing amino acids 257-477 of mouse Tks4.
      Epitopea. a. 257-477
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityThe antibody recognizes mouse Tks4.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteMouse and human (90% homology). Predicted to cross react with rat (96%), horse (88%), canine (87%) and bovine (87%) based on sequence homology. Reactivity with other species has not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Binds a range of phosphoinositides including phosphatidylinositol 3,5-biphosphate and, to a lesser extent, phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate and phosphatidylinositol 5-biphosphate. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
      TISSUE SPECIFICITY: Highly expressed in the stromal-vascular fraction of white adipose tissue with moderate expression in heart, skeletal muscle and the mature adipocyte fraction of white adipose tissue. Expressed in adipocyte-differentiable cells but not in non-adipogenic cells.
      DEVELOPMENTAL STAGE: Expression increases quickly after induction of adipocyte differentiation, reaches a maximum after 3 hours and decreases by 12 hours.
      DOMAIN: The PX domain is required for binding phosphoinositides and can also bind to the third SH3 domain.
      SEQUENCE SIMILARITES: Belongs to the SH3PXD2 family.
      Contains 1 PX (phox homology) domain.
      Contains 4 SH3 domains.
      SEQUENCE CAUTION: The sequence BAC40843.1 differs from that shown. Reason: Frameshift at several positions.
      Molecular Weight~ 130 kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated on a representative lot by Immunoprecipitation followed by Western blot on NIH3T3 cell lysate using Anti-mouse Tks4.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 1 year from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-mouse Tks4 - 2424774 2424774
      Anti-mouse Tks4 - 2433391 2433391
      Anti-mouse Tks4 - 1975097 1975097
      Anti-mouse Tks4 - 2207195 2207195
      Anti-mouse Tks4 - NG1873204 NG1873204
      Anti-mouse Tks4 - NRG1634027 NRG1634027
      Anti-mouse Tks4 -2595525 2595525
      Anti-mouse Tks4 Polyclonal Antibody 3002803
      Anti-mouse Tks4 Polyclonal Antibody 2882999


      Reference overviewPub Med ID
      The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation.
      Buschman, MD; Bromann, PA; Cejudo-Martin, P; Wen, F; Pass, I; Courtneidge, SA
      Molecular biology of the cell  20  1302-11  2009

      Show Abstract Full Text Article
      19144821 19144821
      The SRC substrate Tks5, podosomes (invadopodia), and cancer cell invasion.
      Courtneidge, S A, et al.
      Cold Spring Harb. Symp. Quant. Biol., 70: 167-71 (2005)  2005

      Show Abstract
      16869750 16869750


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