07-571 | Anti-nNOS/NOS I Antibody

07-571
200 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbSerumPolyclonal Antibody
      Description
      Catalogue Number07-571
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-nNOS/NOS I Antibody
      OverviewNote: ADMA (Catalog #19-169) and NMMA (Catalog #19-170) are inhibitors of NOS
      References
      Product Information
      FormatSerum
      Presentation0.05% sodium azide
      Applications
      ApplicationAnti-nNOS/NOS I Antibody is an antibody against nNOS/NOS I for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Biological Information
      ImmunogenSynthetic peptide corresponding to N-terminus of rat nNOS
      HostRabbit
      SpecificitynNOS
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NOS1
      • bNOS
      • nNOS
      • N-NOS
      • IHPS1
      • NC-NOS
      • NOS
      Purification MethodAntiserum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P29475 # Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter.
      COFACTOR: Heme group. & Binds 1 FAD. & Binds 1 FMN. & Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.
      SIZE: 1434 amino acids; 160970 Da
      SUBUNIT: Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity).
      SUBCELLULAR LOCATION: Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).
      TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland.
      DOMAIN: SwissProt: P29475 The PDZ domain in the N-terminal part of the neuronal isoform participates in protein-protein interaction, and is responsible for targeting nNos to synaptic membranes in muscles (By similarity).
      DISEASE: SwissProt: P29475 # Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction.
      SIMILARITY: Belongs to the NOS family. & Contains 1 flavodoxin-like domain. & Contains 1 PDZ (DHR) domain.
      Molecular Weight165kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in a rat brain microsomal preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-nNOS/NOS I (rabbit antiserum) - 2032307 2032307
      Anti-nNOS/NOS I (rabbit antiserum) - DAM1460249 DAM1460249
      Anti-nNOS/NOS I - 27897 27897
      Anti-nNOS/NOS I - DAM1394814 DAM1394814
      Anti-nNOS/NOS I - DAM1479608 DAM1479608
      Anti-nNOS/NOS I - DAM1567216 DAM1567216
      Anti-nNOS/NOS I - DAM1604976 DAM1604976
      Anti-nNOS/NOS I - DAM1713228 DAM1713228
      Anti-nNOS/NOS I - DAM1776468 DAM1776468

      References

      Reference overviewApplicationSpeciesPub Med ID
      Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy.
      Lai, Yi, et al.
      Hum. Mol. Genet., (2014)  2014

      Show Abstract
      24463882 24463882
      Spinal nNOS regulates phrenic motor facilitation by a 5-HT2B receptor- and NADPH oxidase-dependent mechanism.
      MacFarlane, PM; Vinit, S; Mitchell, GS
      Neuroscience  269  67-78  2014

      Show Abstract
      24680940 24680940
      Effect of octreotide on enteric motor neurons in experimental acute necrotizing pancreatitis.
      Zhou, H; Gao, J; Zou, D; Wu, W; Li, Z
      PloS one  7  e52163  2012

      Show Abstract
      23300603 23300603
      A study of the spatial protein organization of the postsynaptic density isolated from porcine cerebral cortex and cerebellum.
      Yun-Hong, Y; Chih-Fan, C; Chia-Wei, C; Yen-Chung, C
      Molecular & cellular proteomics : MCP  10  M110.007138  2011

      Show Abstract
      21715321 21715321
      Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain.
      D'Mello, R; Marchand, F; Pezet, S; McMahon, SB; Dickenson, AH
      Molecular therapy : the journal of the American Society of Gene Therapy  19  1780-92  2011

      Show Abstract
      21427709 21427709
      Damage of the interstitial cells of Cajal and myenteric neurons causing ileus in acute necrotizing pancreatitis rats.
      Hui Zhou,Li Liu,Yu Bai,Wenbin Wu,Guixiang Li,Jianping Li,Duowu Zou,Jun Gao,Zhaoshen Li
      Surgery  149  2011

      Show Abstract
      20570303 20570303
      Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury.
      Li, SY; Yang, D; Yeung, CM; Yu, WY; Chang, RC; So, KF; Wong, D; Lo, AC
      PloS one  6  e16380  2011

      Show Abstract
      ImmunohistochemistryMouse21298100 21298100
      A rat model of smoke inhalation injury: influence of combustion smoke on gene expression in the brain.
      Heung M Lee,George H Greeley,David N Herndon,Mala Sinha,Bruce A Luxon,Ella W Englander
      Toxicology and applied pharmacology  208  2005

      Show Abstract
      15893353 15893353
      The DDAH/ADMA/NOS pathway.
      Tran, Cam T L, et al.
      Atherosclerosis. Supplements, 4: 33-40 (2003)  2003

      Show Abstract
      14664901 14664901
      AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.
      Chen, Z P, et al.
      Am. J. Physiol. Endocrinol. Metab., 279: E1202-6 (2000)  2000

      Show Abstract
      11052978 11052978

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress

      Technical Info

      Title
      White Paper- Modern Methods in Oxidative Stress Research

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies