04-391 | Anti-p70 S6 Kinase Antibody, rabbit monoclonal

04-391
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RFC, IH(P), IP, WBRbPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-391
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-p70 S6 Kinase Antibody, rabbit monoclonal
      Alternate Names
      • RPS6KB1
      • PS6K
      • S6K
      • S6K1
      • STK14A
      • p70(S6K)-alpha
      • p70-S6K
      • p70-alpha
      • p70 S6 kinase, alpha 1
      • p70 S6 kinase, alpha 2
      • ribosomal protein S6 kinase
      References
      Product Information
      FormatPurified
      Presentation100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
      Applications
      ApplicationPlease note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect p70 S6 Kinase using this Anti-p70 S6 Kinase Antibody, rabbit validated for use in FC, IH(P), IP & WB.
      Key Applications
      • Flow Cytometry
      • Immunohistochemistry (Paraffin)
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the N-terminal region of human p70 S6 Kinase.
      HostRabbit
      SpecificityRecognizes the N-terminal domain of both αI and αII isoforms of p70 S6 Kinase.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
      Gene Symbol
      • RPS6KB1
      • p70-alpha
      • p70S6k
      • p70-S6K
      • p70
      • S6K
      • S6Kalpha)
      • P70S6K
      • STK14A
      • S6K1
      • p70(S6K)-alpha
      • PS6K
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
      SIZE: 525 amino acids; 59140 Da
      SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
      TISSUE SPECIFICITY: Widely expressed.
      SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Molecular Weight70 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-p70 S6 Kinase, rabbit monoclonal (Rabbit monoclonal IgG) - 2087725 2087725
      Anti-p70 S6 Kinase, rabbit monoclonal (Rabbit monoclonal IgG) - 2204884 2204884
      Anti-p70 S6 Kinase, rabbit monoclonal - 2428506 2428506
      Anti-p70 S6 Kinase, rabbit monoclonal - 1990412 1990412
      Anti-p70 S6 Kinase, rabbit monoclonal - 2042727 2042727
      Anti-p70 S6 Kinase, rabbit monoclonal - 2048777 2048777
      Anti-p70 S6 Kinase, rabbit monoclonal - DAM1411348 DAM1411348
      Anti-p70 S6 Kinase, rabbit monoclonal - DAM1528112 DAM1528112
      Anti-p70 S6 Kinase, rabbit monoclonal - DAM1581047 DAM1581047
      Anti-p70 S6 Kinase, rabbit monoclonal - DAM1647889 DAM1647889

      References

      Reference overviewPub Med ID
      A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
      Bachmann, Rebecca A, et al
      J Biol Chem, 281:7357-63 (2006)  2006

      16407298 16407298
      Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
      Ohanna, Mickael, et al
      Nat Cell Biol, 7:286-94 (2005)  2005

      15723049 15723049
      Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
      Chiang, Gary G and Abraham, Robert T
      J Biol Chem, 280:25485-90 (2005)  2005

      15899889 15899889

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies