06-926 | Anti-p70 S6 Kinase (S6K) Antibody

06-926
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number06-926
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-p70 S6 Kinase (S6K) Antibody
      Alternate Names
      • RPS6KB1
      • PS6K
      • S6K
      • S6K1
      • STK14A
      • p70(S6K)-alpha
      • p70-S6K
      • p70-alpha
      • ribosomal protein S6 kinase, 70kDa
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the additional of glycerol to 30%
      Applications
      ApplicationAnti-p70 S6 Kinase (S6K) Antibody detects level of p70 S6 Kinase (S6K) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide (C-FPMISKRPEHLRMNL) corresponding to residues 511-525 of rat S6 kinase
      HostRabbit
      Specificityp70 S6 kinase
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
      Gene Symbol
      • RPS6KB2
      • P70-beta-1
      • p70-S6KB
      • S6K2
      • S6K-beta
      • P70-BETA
      • STK14B
      • p70S6Kb
      • p70-beta
      • P70-beta-2
      • S6K-beta2
      • p70(S6K)-beta
      • KLS
      • SRK
      • P70-beta
      Purification MethodProtein A chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UBS0 # Phosphorylates specifically ribosomal protein S6.
      SIZE: 482 amino acids; 53483 Da
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q9UBS0 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Molecular Weight64kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from mouse 3T3 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-p70 S6 Kinase (S6K) - 18062 18062
      Anti-p70 S6 Kinase (S6K) - 20660 20660
      Anti-p70 S6 Kinase (rabbit polyclonal IgG) 2870504
      Anti-p70 S6 Kinase (rabbit polyclonal IgG) 2943597
      Anti-p70 S6 Kinase (rabbit polyclonal IgG) - DAM1437272 DAM1437272
      Anti-p70 S6 Kinase - DAM1604971 DAM1604971
      Anti-p70 S6 Kinase - DAM1692619 DAM1692619
      Anti-p70 S6 Kinase - DAM1751935 DAM1751935
      Anti-p70 S6 Kinase - DAM1754395 DAM1754395
      Anti-p70 S6 Kinase - JBC1858427 JBC1858427

      References

      Reference overviewApplicationPub Med ID
      SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
      Cohet, N; Stewart, KM; Mudhasani, R; Asirvatham, AJ; Mallappa, C; Imbalzano, KM; Weaver, VM; Imbalzano, AN; Nickerson, JA
      Journal of cellular physiology  223  667-78  2010

      Show Abstract
      Western Blotting20333683 20333683
      Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state
      Chen, D., et al
      Mol Cell Biol, 19:4684-94 (1999)  1999

      Immunoprecipitation10373517 10373517
      Activation of an S6 kinase from human placenta by autophosphorylation.
      Dennis, P B and Masaracchia, R A
      J. Biol. Chem., 268: 19833-41 (1993)  1993

      Show Abstract
      8366121 8366121

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies