05-509 | Anti-p73β Antibody, clone GC15

05-509
200 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      B, H, Ht, MkEMSA, IP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-509
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-p73β Antibody, clone GC15
      OverviewThis antibody does not effectively blot p73α, but will immunoprecipitate p73α under non-denaturing conditions
      References
      Product Information
      FormatPurified
      Presentation0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, before the addition of glycerol to 30%
      Applications
      ApplicationDetect p73β with Anti-p73 beta Antibody, clone GC15 (Mouse Monoclonal Antibody), that has been shown to work in EMSA, IP & WB.
      Key Applications
      • Electrophoretic Mobility Shift Assay
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenGST fusion corresponding to residues 380-499 of p73 beta
      Cloneclone GC15
      HostMouse
      Specificityp73β and p73 splice variants
      IsotypeIgG
      Species Reactivity
      • Bovine
      • Human
      • Hamster
      • Monkey
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TP73
      • p73
      • P73
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15350 # Participates in the apoptotic response to DNA damage. When overproduced, activates transcription from p53-responsive promoters and induces apoptosis. May be a tumor suppressor protein.
      COFACTOR: Binds 1 zinc ion per subunit (By similarity).
      SIZE: 636 amino acids; 69623 Da
      SUBUNIT: The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Found in a complex with p53/TP53 and CABLES1. Isoform Beta interacts with WWOX. Interacts with HECW2.
      SUBCELLULAR LOCATION: Nucleus.
      TISSUE SPECIFICITY: Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas.
      DOMAIN: SwissProt: O15350 Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain. & The WW-binding motif mediates interaction with WWOX.
      PTM: Isoform alpha (but not isoform beta) is sumoylated on Lys- 627, which potentiates proteasomal degradation but does not affect transcriptional activity.DISEASE:SwissProt: O15350 # Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.
      SIMILARITY: Belongs to the p53 family.
      MISCELLANEOUS: Activated and stabilized by interaction with RANBP9.
      Molecular Weight55-66kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from HFF, HEK293, CHO, A431, or Cos-1 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-p73beta;, clone GC15 - 18412 18412
      Anti-p73beta;, clone GC15 - 27288 27288

      References

      Reference overviewPub Med ID
      Viral oncoproteins discriminate between p53 and the p53 homolog p73.
      Marin, M C, et al.
      Mol. Cell. Biol., 18: 6316-24 (1998)  1998

      Show Abstract
      9774648 9774648

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies