07-1651 Anti-phospho-β Catenin (Ser37) Antibody

100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbAffinity PurifiedPolyclonal Antibody
      Catalogue Number07-1651
      DescriptionAnti-phospho-β Catenin (Ser37) Antibody
      Alternate Names
      • B Catenin (pSer37)
      • Beta-catenin
      • catenin (cadherin-associated protein), beta 1 (88kD)
      • catenin (cadherin-associated protein), beta 1, 88kDa
      • catenin beta-1
      Background InformationCatenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer. After phosphorylation, beta catenin is rapidly degraded into various fragments over time (Tesco G., et al. 1998. J. Biol. Chem. 273(51):33909-33914).
      Product Information
      FormatAffinity Purified
      • Calycullin/Okadoic acid treated and untreated HEK293 cell lysate.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      ApplicationThis Anti-phospho-β Catenin (Ser37) Antibody is validated for use in WB for the detection of phospho-β Catenin (Ser37).
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: 1:500-1:1000 dilution from a representative lot detected Ser37 phosphorylated beta chain in Calyculin A/Okadoic acid treated HEK293 cell lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Phospho-B Catenin (Ser37) near the N-terminus.
      ConcentrationPlease refer to lot specific datasheet.
      Species Reactivity
      • Rat
      Species Reactivity NoteRat and Human. Predicted to react with Mouse, Zebrafish, Xenopus, Chicken based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CTNNB1
      • CTNNB
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~85-90 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Calyculin A and Okadaic acid treated L6 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ser37 phosphorylated beta chain in 10 µg of Calyculin A and Okadaic acid treated L6 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information




      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Phospho-B Catenin (Ser37) -28269692826969
      Anti-Phospho-B Catenin (Ser37) -Q2557019Q2557019
      Anti-phospho- Catenin (Ser37) - NG1602907NG1602907
      Anti-phospho- Catenin (Ser37) - NG1664798NG1664798
      Anti-phospho- Catenin (Ser37) - NG1752515NG1752515
      Anti-phospho-#946; Catenin (Ser37) - 20382932038293
      Anti-phospho-β Catenin (Ser37) - 24296832429683
      Anti-phospho-β Catenin (Ser37) - 24430832443083
      Anti-phospho-β Catenin (Ser37) - 25319172531917


      Reference overviewPub Med ID
      Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.
      Tesco, G; Kim, TW; Diehlmann, A; Beyreuther, K; Tanzi, RE
      The Journal of biological chemistry  273  33909-14  1998

      Show Abstract
      9852041 9852041


      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products Flyer, Volume 2, 2015, Immunology Feature

      Technical Info

      White Paper: Further considerations of antibody validation and usage.

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      Product Families


      Life Science Research > Antibodies and Assays > Primary Antibodies