07-1651 | Anti-phospho-β Catenin (Ser37) Antibody

07-1651
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1651
      Replaces04-1070
      DescriptionAnti-phospho-β Catenin (Ser37) Antibody
      Alternate Names
      • B Catenin (pSer37)
      • Beta-catenin
      • catenin (cadherin-associated protein), beta 1 (88kD)
      • catenin (cadherin-associated protein), beta 1, 88kDa
      • catenin beta-1
      Background InformationCatenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer. After phosphorylation, beta catenin is rapidly degraded into various fragments over time (Tesco G., et al. 1998. J. Biol. Chem. 273(51):33909-33914).
      References
      Product Information
      FormatAffinity Purified
      Control
      • Calycullin/Okadoic acid treated and untreated HEK293 cell lysate.
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationThis Anti-phospho-β Catenin (Ser37) Antibody is validated for use in WB for the detection of phospho-β Catenin (Ser37).
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: 1:500-1:1000 dilution from a representative lot detected Ser37 phosphorylated beta chain in Calyculin A/Okadoic acid treated HEK293 cell lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Phospho-B Catenin (Ser37) near the N-terminus.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Rat
      Species Reactivity NoteRat and Human. Predicted to react with Mouse, Zebrafish, Xenopus, Chicken based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CTNNB1
      • CTNNB
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~85-90 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Calyculin A and Okadaic acid treated L6 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Ser37 phosphorylated beta chain in 10 µg of Calyculin A and Okadaic acid treated L6 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SDS

      Title

      Safety Data Sheet (SDS) 

      Certificates of Analysis

      TitleLot Number
      Anti-Phospho-B Catenin (Ser37) -2826969 2826969
      Anti-Phospho-B Catenin (Ser37) -Q2557019 Q2557019
      Anti-phospho- Catenin (Ser37) - NG1602907 NG1602907
      Anti-phospho- Catenin (Ser37) - NG1664798 NG1664798
      Anti-phospho- Catenin (Ser37) - NG1752515 NG1752515
      Anti-phospho-#946; Catenin (Ser37) - 2038293 2038293
      Anti-phospho-β Catenin (Ser37) - 2429683 2429683
      Anti-phospho-β Catenin (Ser37) - 2443083 2443083
      Anti-phospho-β Catenin (Ser37) - 2531917 2531917

      References

      Reference overviewPub Med ID
      Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation.
      Tesco, G; Kim, TW; Diehlmann, A; Beyreuther, K; Tanzi, RE
      The Journal of biological chemistry  273  33909-14  1998

      Show Abstract
      9852041 9852041

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products Flyer, Volume 2, 2015, Immunology Feature

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies